Screening of benzodizepines and their metabolites in urine

Abstract

Abstract: Objective Screen seventeen benzodizepines and their metabolitesin urine by GC/ECDand GC/MS . Methods They were GC (GC/ECD, GC/MS) assay of benzodizepines and GC (GC/ECD, GC/MS) assay of benzophenones of acid-hydrolytic products of 1,4-benzodizepines. Results The methods were simple and sensitive. The recoverys were 60%to 90%of most benzodizepines, linear calibration curves were 20ng/ml-200ng/ml(r >0.99), and detection limits were 0.5ng/ml-10ng/ml. Conclusion They methods were evaluated with human urine samples.

Key words: benzodizepines, benzophenones, GC/ECD, GC/MS

SHEN BAO-HUA;SHEN MIN;ZHUO XIAN-YI;ET AL.( INSTITUTE OF FORENSIC SCIENCES;MINISTRY OF JUSTICE;SHANGHAI 000). Screening of benzodizepines and their metabolites in urine[J]. , 2002, 0(1): 22-25.

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[9]	XIANG PING;SHEN MIN;SHEN BAO-HUA;ET AL.( INSTITUTE OF FORENSIC SCIENCE;MINISTRY OF JUSTICE;PRC;SHANGHAI000 ). Simultaneous quantification of cannabinoids and the major metabolite,THC-COOH in human hair [J]. , 2002, 0(4): 216-219.
[10]	SUN YAJUAN;ET AL.(INSTITUTE OF FORENSIC SCIENCES;MINISTRY OF JUSTICE;SHANGHAI 000;P.R.CHINA). Determination of fenfluramine in corpse using GC/NPD and GC/MS [J]. , 2000, 0(1): 21-23+6.
[11]	XIANG PING;SHEN MIN;WU HEJIAN;ET AL. (INSTITUTE OFFORENSIC SCISNCES;MINISTRY OF JUSTICE;SHANGHAI000;P. R. CHINA). Determination of heroin metabolites in biological fluids,tissues and hair of heroin addicts using GC/MS-SIM [J]. , 1999, 0(4): 208-210+.
[12]	LIU WEI (INSTITUTE OF FORENSIC SCIENCES;MINISTRY OF JUSTICE;PR. CHINA;SHANGHAI 000). Determination of triazolam in human urine by GC/ECD [J]. , 1998, 0(4): 203-208+.
[13]	SHEN MIN ET AL (INSTITUTE OF FORENSIC SCIENCES;MINISTRY OF JUSTICE;000). Study on the analysis of methamphetamine and its metabolite amphetamine in blood and urine [J]. , 1997, 0(3): 129-132+.
[14]	XIANG PING;SHEN MIN AND SHEN BAOHUA (INSTITUTE OF FORENSIC SCIENSES;SHANGHAI;000). Analysis of the Main Cannabis Metabolite THC-COOH [J]. , 1996, 0(4): 0-0.
[15]	XUE YUEHUA (SHANGHAI FIRST HOSPITAL) SHEN MIN.SHEN BAOHUA XIANG PING AND WU MOUTIAN (INSTITUTE OF FORENSIC .SCIENCES.MINISIRY OF JUSTICE. SHANGHAI;000). The Determination of Meperdine in Human Blood by GC/MS and its Pharmacokinetic Study [J]. , 1996, 0(3): 0-0.

Screening of benzodizepines and their metabolites in urine

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