Immunohistochemical Study on Contents of β-amyloid, α-actin and Collagen Ⅳ in Cerebral Small Vessels with Unknown Type of Pathological Lesion

Abstract

Abstract: Objective To investigate the structural characteristics of the cerebral small vessels with an unknown type of pathological lesion (UTPL). Methods Contents of β-amyloid, α-actin and collagen Ⅳ in cerebral small vessels with UTPL were studied by Congo red staining, immunohistochemical staining and computer image analysis. Results The low expression levels of α-actin and collagen Ⅳ(P<0.05)were observed in tunica media of the vessels with UTPL, and no positive expression of β-amyloid(P>0.05) was observed in these vessel walls. The expressions of proteins mentioned above in UTPL were different from those of cerebral amyloid angiopathy(CAA) and hyaline arteriolosclerosis. Conclusion UTPL was different from CAA or hyaline arteriolosclerosis in pathologic feature.

Key words: unknown type of pathological lesion, cerebral small vessels, immunohistochemistry, β-amyloid, α-actin, collagen Ⅳ

ZHANG MIN;GUAN DA-WEI;ZHAO RUI;HU GENG-YI;HAN YANG;HOU ZHEN-HUAN;SHAN YA-MING (.DEPARTMENT OF FORENSIC PATHOLOGY;SCHOOL OF FORENSIC MEDICINE;CHINA MEDICAL UNIVERSITY;SHENYANG 000;CHINA;.SHENYANG MUNICIPAL INTERMEDIATE PEOPLE′S COU. Immunohistochemical Study on Contents of β-amyloid, α-actin and Collagen Ⅳ in Cerebral Small Vessels with Unknown Type of Pathological Lesion[J]. , 2006, 0(6): 413-416+.

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Immunohistochemical Study on Contents of β-amyloid, α-actin and Collagen Ⅳ in Cerebral Small Vessels with Unknown Type of Pathological Lesion

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