Journal of Forensic Medicine ›› 2024, Vol. 40 ›› Issue (6): 575-577.DOI: 10.12116/j.issn.1004-5619.2023.331001
Special Issue: 高分辨质谱技术专题
• Topic on High Resolution Mass Spectrometry Technology • Previous Articles Next Articles
Received:2023-10-12
Online:2025-03-10
Published:2024-12-25
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URL: http://www.fyxzz.cn/EN/10.12116/j.issn.1004-5619.2023.331001
| 名称 | 氨基酸序列 | 分子式 | 单一同位素质量 |
|---|---|---|---|
| 人胰岛素 | GIVEQCCTSICSLYQLENYCN-FVNQHLCGSHLVEALYLVCGERGFFYTPKT | C257H383N65O77S6 | 5 803.6 |
| 猪胰岛素 | GIVEQCCTSICSLYQLENYCN-FVNQHLCGSHLVEALYLVCGERGFFYTPKA | C256H381N65O76S6 | 5 773.6 |
| 牛胰岛素 | GIVEQCCASVCSLYQLENYCN-FVNQHLCGSHLVEALYLVCGERGFFYTPKA | C254H377N65O75S6 | 5 729.6 |
Tab. 1 Information of 3 types of insulin
| 名称 | 氨基酸序列 | 分子式 | 单一同位素质量 |
|---|---|---|---|
| 人胰岛素 | GIVEQCCTSICSLYQLENYCN-FVNQHLCGSHLVEALYLVCGERGFFYTPKT | C257H383N65O77S6 | 5 803.6 |
| 猪胰岛素 | GIVEQCCTSICSLYQLENYCN-FVNQHLCGSHLVEALYLVCGERGFFYTPKA | C256H381N65O76S6 | 5 773.6 |
| 牛胰岛素 | GIVEQCCASVCSLYQLENYCN-FVNQHLCGSHLVEALYLVCGERGFFYTPKA | C254H377N65O75S6 | 5 729.6 |
| 1 | BOTTINELLI C, CARTISER N, BÉVALOT F, et al. Is insulin intoxication still the perfect crime? Analysis and interpretation of postmortem insulin: Review and perspectives in forensic toxicology[J]. Crit Rev Toxicol,2020,50(4):324-347. doi:10.10 80/10408444.2020.1762540 . |
| 2 | MATHIEU C, MARTENS P J, VANGOITSENHO-VEN R. One hundred years of insulin therapy[J]. Nat Rev Endocrinol,2021,17(12):715-725. doi:10.1038/s41574-021-00542-w . |
| 3 | LABAY L M, BITTING C P, LEGG K M, et al. The determination of insulin overdose in postmortem investigations[J]. Acad Forensic Pathol,2016,6(2):174-183. doi:10.23907/2016.019 . |
| 4 | ARBOUCHE N, GODARD E, GHEDDAR L, et al. Attempted murder of a young child followed by an attempted suicide of the mother by injection of insulin aspart: Identification of quantification of insulin by LC-HRMS and UPLC-MS-MS in blood of the two cases[J]. J Anal Toxicol,2022,46(2):e65-e72. doi:10.1093/jat/bkab097 . |
| 5 | 刘宏,李成杰. 静脉输入胰岛素后被捂死1例[J].法医学杂志,2010,26(4):313. doi:10.3969/j.issn.1004-5619.2010.04.027 . |
| LIU H, LI C J. Smothering after intravenous insulin injection: A case report[J]. Fayixue Zazhi,2010,26(4):313. | |
| 6 | THOMAS A, BENZENBERG L, BALLY L, et al. Facilitated qualitative determination of insulin, its synthetic analogs, and C-peptide in human urine by means of LC-HRMS[J]. Metabolites,2021,11(5):309. doi:10.3390/metabo11050309 . |
| 7 | SEBASTIAN S A, CO E L, MEHENDALE M, et al. Insulin analogs in the treatment of type Ⅱ diabetes and future perspectives[J]. Dis Mon,2023,69(3):101417. doi:10.1016/j.disamonth.2022.101417 . |
| 8 | THOMAS A, YANG R, PETRING S, et al. Simplified quantification of insulin, its synthetic analogs and C-peptide in human plasma by means of LC-HRMS[J]. Drug Test Anal,2020,12(3):382-390. doi:10.1002/dta.2765 . |
| 9 | THOMAS A, THEVIS M. Recent advances in the determination of insulins from biological fluids[J]. Adv Clin Chem,2019,93:115-167. doi:10.1016/bs.acc.2019.07.003 . |
| 10 | 童昉,梁悦,石青,等. 胰岛素中毒法医学研究进展[J].法医学杂志,2017,33(1):48-51,57. doi:10.3969/j.issn.1004-5619.2017.01.012 . |
| TONG F, LIANG Y, SHI Q, et al. Advance of forensic research in insulin poisoning[J]. Fayixue Zazhi,2017,33(1):48-51,57. | |
| 11 | ARBOUCHE N, WALCH A, RAUL J S, et al. Intentional overdose of glargine insulin: Determination of the parent compound in postmortem blood by LC-HRMS[J]. J Forensic Sci,2023,68(3):1077-1083. doi:10.1111/1556-4029.15247 . |
| 12 | LUTZ R, PEDAL I, WETZEL C, et al. Insulin injection sites: Morphology and immunohistochemistry[J]. Forensic Sci Int,1997,90(1/2):93-101. doi:10.1016/s0379-0738(97)00153-9 . |
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