法医学杂志 ›› 2026, Vol. 42 ›› Issue (2): 151-158.DOI: 10.12116/j.issn.1004-5619.2024.340703
收稿日期:2024-07-02
发布日期:2026-06-10
出版日期:2026-04-25
通讯作者:
钱振华
作者简介:沈瑞迪(1995—),女,硕士,主要从事毒品检验与鉴定;E-mail:850182974@qq.com
基金资助:Received:2024-07-02
Online:2026-06-10
Published:2026-04-25
Contact:
Zhenhua QIAN
摘要:
新精神活性物质在全球范围内的滥用严重,苯乙胺类物质中的麦司卡林及其类似物作为其中一类常被忽视的物质,近年来滥用趋势逐渐增强。本文从麦司卡林及其类似物的基本情况、药理毒理学性质及检测方法3个方面进行综述,以期为麦司卡林及其类似物的深入研究提供思路,并对法庭科学中涉及麦司卡林及其类似物的检验提供参考。
中图分类号:
沈瑞迪, 钱振华. 麦司卡林及其类似物的研究进展[J]. 法医学杂志, 2026, 42(2): 151-158.
Ruidi SHEN, Zhenhua QIAN. Research Progress on Mescaline and Its Analogues[J]. Journal of Forensic Medicine, 2026, 42(2): 151-158.
| 编号 | 物质 | 样本 | 分析方法 | 特征离子(m/z) | 参考文献 |
|---|---|---|---|---|---|
| 1 | 麦司卡林 | 毛发 | UPLC-MS/MS | 212.14、195.13、180.11、165.07 | [ |
| 2 | 乙基麦司卡林 | 液体及粉末 | GC-MS | 225、196、167 | [ |
| 3 | TMA | 粉末 | GC-MS | 225(M+)、182、167、44 | [ |
| 4 | TMA-2 | 粉末 | GC-MS | 225(M+)、182、167、151、44 | [ |
| 5 | TMA | 血液 | LC-MS/MS | 226.0、209.1、194.1、181.1 | [ |
| 6 | N,N-二甲酰基麦司卡林 | 粉末 | GC-MS | 267、181、194、179 | [ |
| 7 | 甲基烯丙基麦司卡林 | 人肝细胞 | LC-HRMS | 252.159 4、235.132 9、203.106 8、181.085 9、167.070 3 | [ |
表1 体外检材及生物检材中麦司卡林及其类似物的分析方法及特征碎片离子
Tab. 1 Analysis methods and characteristic fragment ions of mescaline and its analoguesin in vitro and biological specimens
| 编号 | 物质 | 样本 | 分析方法 | 特征离子(m/z) | 参考文献 |
|---|---|---|---|---|---|
| 1 | 麦司卡林 | 毛发 | UPLC-MS/MS | 212.14、195.13、180.11、165.07 | [ |
| 2 | 乙基麦司卡林 | 液体及粉末 | GC-MS | 225、196、167 | [ |
| 3 | TMA | 粉末 | GC-MS | 225(M+)、182、167、44 | [ |
| 4 | TMA-2 | 粉末 | GC-MS | 225(M+)、182、167、151、44 | [ |
| 5 | TMA | 血液 | LC-MS/MS | 226.0、209.1、194.1、181.1 | [ |
| 6 | N,N-二甲酰基麦司卡林 | 粉末 | GC-MS | 267、181、194、179 | [ |
| 7 | 甲基烯丙基麦司卡林 | 人肝细胞 | LC-HRMS | 252.159 4、235.132 9、203.106 8、181.085 9、167.070 3 | [ |
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