法医学杂志

法医学杂志 ›› 2014, Vol. 30 ›› Issue (6): 413-415.DOI: 10.3969/j.issn.1004-5619.2014.06.002

• 论著 • 上一篇    下一篇

单核细胞趋化蛋白1及其受体在冠心病猝死中的表达

匡圆圆，陈霞霞，王苍成，叶  坤，王  颖，史永华   

  1. （新疆医科大学基础医学院，新疆 乌鲁木齐 830011）
  • 发布日期:2014-12-25 出版日期:2014-12-28
  • 通讯作者: 史永华，女，博士，副教授，主要从事法医病理学研究；E-mail：z5826711@126.com
  • 作者简介:匡圆圆（1992—），女，新疆乌鲁木齐人，主要从事法医病理学研究；E-mail：1642508892@qq.com

Expression of Monocyte Chemotactic Protein-1 and Its Receptor in Sudden Coronary Death

KUANG YUAN-YUAN, CHEN XIA-XIA, WANG CANG-CHENG, YE KUN, WANG YING, SHI YONG-HUA   

  1. （School of Basic Medical Science, Xinjiang Medical University, Urumqi 830011, China）
  • Online:2014-12-25 Published:2014-12-28

被引次数

7

摘要： 目的 探讨单核细胞趋化蛋白1（monocyte chemotactic protein-1，MCP-1）及其受体CC类趋化蛋白受体2（CC chemokine receptor-2，CCR-2）在冠心病猝死（sudden coronary death，SCD）和非SCD冠状动脉粥样硬化斑块中的差异表达。 方法 应用免疫组织化学方法检测MCP-1和CCR-2在SCD组、动脉粥样硬化组（冠状动脉粥样硬化但非SCD）、对照组（冠状动脉正常）的差异表达。 结果 MCP-1在三组间的阳性细胞表达率分别是78%、47%、0%，两两比较差异均有统计学意义（P＜0.05）；CCR-2在三组间的阳性细胞表达率分别是72%、47%、0%，在SCD组和动脉粥样硬化组、SCD组与对照组表达差异均有统计学意义（P<0.05），而在对照组和动脉粥样硬化组差异无统计学意义（P>0.05）。 结论 冠状动脉粥样硬化斑块中的MCP-1及其受体CCR-2的表达增加与SCD密切相关。

关键词: 法医病理学；猝死, 心脏；单核细胞趋化蛋白1；CC类趋化蛋白受体2

Abstract: Objective To investigate the expression of monocyte chemotactic protein-1 （MCP-1） and its receptor CC chemokine receptor-2 （CCR-2） in coronary atherosclerosis plaques between sudden coronary death （SCD） and non-SCD. Methods The expression levels of MCP-1 and CCR-2 in SCD group, coronary atherosclerosis group （non-SCD）, control group （normal coronary artery） were detected by immunohistochemistry. Results Positive rates of MCP-1 among the three groups were 78%, 47%, and 0%, respectively, with significant expressing differences between each two groups （P＜0.05）. Positive rates of CCR-2 among three groups were 72%, 47%, and 0%, respectively, with significant expressing differences between the SCD group and coronary atherosclerosis group as well as between the SCD group and control group （P<0.05）, but with no significant expressing difference between coronary atherosclerosis group and control group （P>0.05）. Conclusion Overexpression of MCP-1 and CCR-2 in coronary atherosclerotic plaques is closely correlated with SCD.

Key words: forensic pathology, death, sudden, cardiac, monocyte chemotactic protein-1, CC chemokine protein receptor-2

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