法医学杂志

法医学杂志 ›› 1993, Vol. 0 ›› Issue (4): 148-150+.

• 论文 • 上一篇    下一篇

儿茶酚胺致心肌损伤的病理实验研究

姚季生;应爱娣;颜召文;佘伟良;韩玉升;   

  1. 上海第二医科大学法医学教研室,上海第二医科大学法医学教研室,上海第二医科大学法医学教研室,上海第二医科大学法医学教研室,上海第二医科大学法医学教研室 上海 200025,上海 200025,上海 200025,上海 200025,上海 200025
  • 发布日期:1993-08-25 出版日期:1993-08-28

AN EXPERIMENTAL PATHOLOGICAL STUDY OF MYOCARDIAL DAMAGE INDUCED BY CATECHOLAMINE

YAO JISHENG.SHANGHAI SECOND MEDICAL UNIVERSITY;SHANGHAI.(200025)   

  • Online:1993-08-25 Published:1993-08-28

被引次数

3

摘要： 大鼠尾静脉滴注去甲肾上腺素后不同时期(即刻、7、30、90、150天)分别处死取材,用病理组织学、肌红蛋白免疫组化染色及透射电镜观察心肌损伤。结果:急性期心肌呈多灶性坏死,肌红蛋白缺染,肌原纤维溶解断裂,类似人冠状动脉无阻塞性心肌梗塞;急性期后心肌继续灶性溶解、萎缩,成纤维细胞增生活跃,新生胶原纤维伸入心肌坏死灶及其周围间隙,使病灶疤痕化及内膜增厚,类似人早期心肌病病理图象。

关键词: 心源性猝死, 去甲肾上腺素, 肌红蛋白免疫组化, 心肌超微结构, 心肌梗死

Abstract: An experimental study of myocardial damage was induced in Wistar rats following noradrenaline infusion(20 ug/kg body wt/minute),for a period of 90 minutes daily for three consecutive days,the animals were killed after some minutes(acute phase),7 days(subacute phase),30-90 days(chron- ic phase),observed by histopathological,myoglobin immunohisto-chemical and ultrastructural me- thods.The results demonstrated multiple focal necrosis and myoglobin defects of myocytes,my- ofibrillar fragmentation and dissolution in the acute phase,this morphological feature simulated human cases of myocardial infarction without coronary occlusion.After acute phase,focal atrophy and scars of myocardium,active proliferaton of fi- bre(?) asts and neo-collageous fibrils infiltrated in r(?)crofic myocytes are present,this feature si rula- ted the early cardio-myopathy.