法医学杂志 ›› 2019, Vol. 35 ›› Issue (1): 68-73.DOI: 10.12116/j.issn.1004-5619.2019.01.013

• 综述 • 上一篇    下一篇

心肌梗死后交感神经重构的研究进展及其法医学意义

于天水1,2, 葛鲁邹3, 曹济民4   

  1. 1. 司法文明协同创新中心,北京 100088; 2. 中国政法大学 证据科学教育部重点实验室,北京 100192; 3. 威海市公安局高区分局,山东 威海 264200; 4. 山西医科大学生理学系 细胞生理学教育部重点实验室,山西 太原 030001
  • 发布日期:2019-02-25 出版日期:2019-02-28
  • 通讯作者: 曹济民,男,博士后,教授,博士研究生导师,主要从事心律失常、心脏性猝死机制、生物钟机制及纳米生物学研究;E-mail:caojimin@126.com
  • 作者简介:于天水(1982—),男,博士,副教授,硕士研究生导师,副主任法医师,主要从事法医病理学教学、科研及鉴定;E-mail: yutianshui-2000@qq.com
  • 基金资助:
    中国政法大学青年教师学术创新团队支持计划资助项目(18CXTD09);北京市自然科学基金资助项目(7182106);上海市法医学重点实验室(司法鉴定科学研究院)开放课题资助项目(KF1401)

Research Advances in Sympathetic Remodeling after Myocardial Infarction and Its Significance in Forensic Science#br#

YU Tian-shui1,2, GE Lu-zou3, CAO Ji-min4   

  1. 1. Collaborative Innovation Center of Judicial Civilization, Beijing 100088, China; 2. Key Laboratory of Evidence Science, Ministry of Education, China University of Political Science and Law, Beijing 100192, China; 3. High District Branch of Weihai Public Security Bureau, Weihai 264200, Shandong Province, China; 4. Key Laboratory of Cellular Physiology, Ministry of Education, Department of Physiology, Shanxi Medical University, Taiyuan 030001, China
  • Online:2019-02-25 Published:2019-02-28

摘要: 心肌梗死后交感神经重构表现为去神经支配、交感神经芽生及交感神经分布密度增高,与心肌梗死患者恢复期发生室性快速心律失常甚至心脏性猝死密切相关。本文综述了心脏交感神经解剖结构、交感神经形态和功能重构及其在陈旧性心肌梗死鉴定中的作用,以期为法医学研究提供参考。

关键词: 法医病理学, 心肌梗死, 猝死, 心脏, 交感神经重构, 综述

Abstract: Sympathetic remodeling after myocardial infarction is presented as denervation, sympathetic nerve sprouting and sympathetic hyperinnervation, and is closely related to ventricular tachyarrhythmias and even sudden cardiac death at convalescence in patients with myocardial infarction. This article reviews the anatomic structure, morphology and functional remodeling of cardiac sympathetic nerve, as well as its role in healed myocardial infarction identification, which may provide references for forensic research.

Key words: forensic pathology, myocardial infarction, death, sudden, cardiac, sympathetic remodeling, review