法医学杂志

法医学杂志 ›› 2019, Vol. 35 ›› Issue (1): 63-67.DOI: 10.12116/j.issn.1004-5619.2019.01.012

• 技术与应用 • 上一篇    下一篇

新疆阿克苏地区维吾尔族人群17个STR基因座遗传多态性

杨扬， 童继军   

  1. 金华市公安司法鉴定中心，浙江 金华 321000
  • 发布日期:2019-02-25 出版日期:2019-02-28
  • 作者简介:杨扬（1986—），男，硕士，主要从事法医物证学鉴定及研究；E-mail：y_y0629@163.com

Genetic Polymorphism of 17 STR Loci in Uygur Population of Akesu in Xinjiang

YANG Yang, TONG Ji-jun   

  1. Forensic Identification Center, Jinhua Public Security Bureau, Jinhua 321000, Zhejiang Province, China
  • Online:2019-02-25 Published:2019-02-28

PDF (PC)

1131

摘要： 目的 调查新疆阿克苏地区维吾尔族人群17个STR基因座的遗传多态性。 方法 应用17+1试剂盒对新疆阿克苏地区维吾尔族10 094名无关个体血样进行复合扩增和检测，得到17个STR基因座分型，统计各基因座等位基因分布和群体遗传学参数，并与中国汉族、伊犁地区维吾尔族、和田地区维吾尔族、吐鲁番地区维吾尔族进行差异性比较。 结果 在10 094名维吾尔族无关个体中共发现252个等位基因，经卡方检验，除vWA基因座外，均符合Hardy-Weinberg平衡，D13S317等14个基因座为高鉴别力基因座。17个STR基因座在阿克苏地区维吾尔族人群和中国汉族人群中等位基因分布频率存在差异，与三个新疆维吾尔族群体表现为部分基因座存在差异。 结论 17个STR基因座均具有较强的个体识别能力，获得的数据可为新疆阿克苏地区法医学实践中的个体识别和亲权鉴定提供科学的基础数据。

关键词: 法医遗传学, 多态现象, 遗传, 短串联重复, 维吾尔族, 新疆

Abstract: Objective To investigate the genetic polymorphisms of 17 STR loci in Uygur population of Akesu in Xinjiang Uygur Autonomous Region. Methods Blood samples from 10 094 unrelated individuals of Uygur population of Akesu in Xinjiang were amplified by using the 17+1 PCR amplification kit, and 17 STR loci typing were detected. Allele distribution and population genetic parameters of each locus were calculated, and compared with those of Chinese Han population, and Uygur population of Yili, Hotan and Turpan regions. Results In the 10 094 unrelated Uygur individuals, 252 alleles were detected. All loci meet the Hardy-Weinberg equilibrium using a chi-square goodness-of-fit test expectation except vWA loci. Fourteen out of the 17 STR loci, including D13S317, showed high power of discrimination. A significant difference on the allele distribution of all the 17 STR loci was observed between Uygur population of Akesu and Chinese Han population, and the difference of some loci existed between Uygur population of Akesu and the other three Uygur populations. Conclusion The 17 STR loci are highly polymorphic genetic markers, and the polymorphic information could serve as reference data for forensic individual identification and paternity identification in Akesu.

Key words: forensic genetics, polymorphism, genetic, short tandem repeat, Uygur nationality, Xinjiang