法医学杂志

法医学杂志 ›› 2002, Vol. 0 ›› Issue (1): 48-51.

• 论文 • 上一篇    下一篇

应激与海马

蔡伟雄,杨德森   

  1. 司法部司法鉴定科学技术研究所,中南大学湘雅二院精神卫生研究所 上海200063 ,湖南长沙410011
  • 发布日期:2002-02-25 出版日期:2002-02-28

Stress and hippocampus

CAI WEI-XIONG1, YANG DE-SEN2 (1. INSTITUTE OF FORENSIC SCIENCES, MINISTRY OF JUSTICE, P. R. CHINA, SHANGHAI, 200063, 2. DEPARTMENT OF MENTAL HEALTH, THE SECOND XIANGYA HOSPITAL, CENTRAL SOUTH UNIVERSITY, CHANGSHA, 410011)   

  • Online:2002-02-25 Published:2002-02-28

被引次数

24

摘要： 综述了近年来应激对海马形态和功能影响及海马对应激(HPA轴)调节的研究进展。研究表明,由于海马参与应激的感知、整合与评价,参与HPA轴应激反应,应激影响其结构与功能;而海马又可通过负反馈调节,抑制HPA轴的过度应激反应。但长期慢性应激则可削弱这种抑制作用,加重海马结构与功能的损害。

关键词: 应激, 海马, HPA轴

Abstract: This review summarizes the present advance of effects of stress on hippocampal structure and function and the role of hippocampus in feedback regulation of thalamic-pituitary-adrenocortical (HPA)axis during stress. It shows that stress can affect hippocampal structure and function, on the other hand,the hippocampus can also suppress the stress reaction through the feedback regulation of HPA axis,but chronic stress can attenuate this regulation, then significantly impair its structure and function.

Key words: stress, hippocampus, HPA axis