法医学杂志

法医学杂志 ›› 2007, Vol. 0 ›› Issue (2): 97-100.

• 论文 • 上一篇    下一篇

TW_2、TW_3法腕骨骨龄评价方法的诊断性试验

宁刚;曲海波;刘关键;吴康敏;谢蜀祥;陈锡建;   

  1. 四川大学华西第二医院,四川大学华西第二医院,华西临床医学院统计学教研室,四川大学华西第二医院,四川大学华西第二医院,四川大学华西第二医院 四川成都610041,四川成都610041,四川成都610041,四川成都610041,四川成都610041,四川成都610041
  • 发布日期:2007-04-25 出版日期:2007-04-28

TW Systems in Estimation of Carpal Bone Age and Their Potential Applications in Diagnosis of Idiopathic Precocious Puberty in Chinese Girls

NING GANG1,QU HAI-BO1,LIU GUAN-JIAN2,WU KANG-MIN1,XIE SHU-XIANG1,CHEN XI-JIAN1(1.THE 2ND WEST CHINA HOSPITAL OF SICHUAN UNIVERSITY,CHENGDU 610041,CHINA;2.DEPARTMENT OF CLINICAL EPIDEMIOLOGY OF SICHUAN UNIVERSITY,CHENGDU 610041,CHINA)   

  • Online:2007-04-25 Published:2007-04-28

摘要： 目的比较TW2法英国人标准、TW2法中国人南方标准和TW3法测定腕骨骨龄对特发性性早熟(IPP)女孩的诊断价值。方法女性IPP患儿55例;对照组83例。回顾性分析初诊左腕X线片,用TW2法、TW2CHC中国人南方标准和TW3法盲法分期,分别测得其腕骨骨龄及其百分位,并分为5个连续性的工作点,即:>P97、>P90、>P75、>P50和、≤P50。结果敏感度(Sen)和特异度(Spe)都比较高的有以下3个工作点:TW2CH“>P90”点,TW3“>P90”点,TW2“>P90”点。结论TW系统3种腕骨骨龄对于IPP女孩都有诊断价值,TW3法和TW2法中国人南方标准诊断价值比较高,TW2法英国人标准的诊断价值为中等。

关键词: 骨龄测定, TW2法, TW3法, 特发性性早熟, 诊断性试验

Abstract: Objective To compare three assessment methods(TW2,TW2CH,and TW3) for carpal bone age and their potential applications in diagnosis of idiopathic precocious puberty(IPP) in Chinese girls.Methods Fifty-five(55) girls with IPP and 83 normal girls as control group were selected in this study.The X-ray films of the left hand-wrist taken at their first visit were analyzed retrospectively.Three assessment methods were used to estimate the carpal bone age with single-blinded method and percentiles were set at 5 different decision thresholds(1) >97th percentile,(2) >90 th percentile,(3) >75th percentile,(4) >50 th percentile,and(5) ≤50 th percentile.Results All of the three methods showed similar high sensitivity and specificity at the threshold above 90th percentile.Conclusion Our data indicate that all of the three methods for estimation of the carpal bone age are useful in diagnosis of IPP.TW2CH and TW3 methods appear to be superior to TW2 method.

Key words: bone age estimation, TW2 methods, TW3 method, idiopathic precocious puberty, diagnostic usefulness