法医学杂志

法医学杂志 ›› 1996, Vol. 0 ›› Issue (2): 0-0.

• 论文 •    

度冷丁滥用者尿中原体及其代谢产物的分析研究

沈敏，薛月华，沈保华，向平，刘伟   

  1. 司法部司法鉴定科学技术研究所，上海市第一人民医院护士学校
  • 发布日期:1996-04-25 出版日期:1996-04-28

Studies on the Analysis of Meperidine and its Main Metabolites in urine of Meperidine Addicts

SHEN MIN; XUE YUEHUA; SHEN BAO HUA;XIANG PING; LIU WEI (INSTITUTE OF FORENSIC SCIENCES,MINISTRY OF JUSTICE; SHANGHAI 200063), (SHANGHAI FIRST HOSPITAL)   

  • Online:1996-04-25 Published:1996-04-28

被引次数

7

摘要： 本研究利用ＧＣ／ＭＳ（ＥＩ．ＰＣＩ）技术，在度冷丁滥用者尿中确认了６种代谢产物。并建立了ＧＣ／ＦＩＤ分析度冷丁及其代谢产物的方法。方法线性范围为０．１～２０μｇ／ｍｌ，变异系数小于１０％，最小检出量为５０ｎｇ／ｍｌ，适用于度冷丁成瘾者尿中含量的测定。

关键词: 度冷丁, 去甲度冷丁, 尿, 气相色谱法, 气质联用法

Abstract: Six meperidine metabolites are identified by GC/MS(EI, PCI) in the urine of meperidine addicts.A GC/FID procedure for determination of meperidine and its main metabolites in human urine is also developed. Calibration curve is lineat over the rang 0. 1-20ug/ml, me results reproducible (cv<10%), the sensitivity limit is about 50ng/ml.The method is shown to be applicable to measuring urine concentra-tion of meperidine addicts.

Key words: meperidine, normeperidine, urine, GC/FID, DC/MS