法医学杂志

法医学杂志 ›› 2004, Vol. 0 ›› Issue (4): 250-252.

• 论文 • 上一篇    下一篇

缝隙连接、连接蛋白与冠心病猝死

章诗伟,陈新山,刘世新,张益鹄   

  1. 华中科技大学同济医学院法医学系,华中科技大学同济医学院法医学系,华中科技大学同济医学院法医学系,华中科技大学同济医学院法医学系 湖北武汉430030 ,湖北武汉430030 ,湖北武汉430030 ,湖北武汉430030
  • 发布日期:2004-08-25 出版日期:2004-08-28

Gap Junctions, Connexins and Sudden Death Caused by Coronary Heart Disease

ZHANG SHI-WEI,CHEN XIN-SHAN,LIU SHI-XIN, ET AL. (FACULTY OF FORENSIC MEDICINE,TONGJI MEDICAL COLLEGE, HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY,WUHAN,430030,CHINA)   

  • Online:2004-08-25 Published:2004-08-28

被引次数

5

摘要： 缝隙连接(gapjunction,GJ)构成细胞之间的跨膜水相通道,协调细胞间化学及电信息的交流。心脏上缝隙连接的主要功能是为心肌细胞间的电冲动提供低压传导通路,并维持心肌的协调运动。近年来的研究显示,心肌细胞(特别是心室肌工作细胞)上构成缝隙连接的连接蛋白含量、分布及功能的异常与各种心律失常的产生和持续关系密切。这很可能为临床及法医实践中,诊断冠心病猝死心肌早期病变提供一个新的思路。

关键词: 缝隙连接, 连接蛋白, 猝死, 冠心病

Abstract: Gap junctions construct hydrophilic trans-membrane channels which adjust the intercellular communication of chemistry and electricity. In the heart, individual cardiac myocytes are linked by gap junctions. These junctions form low resistance pathways along which the electrical impulse flows rapidly and repeatedly between all the myocardium, ensuring their synchronous contraction. In recent years, some researchers have found that connexins, the protein molecules of gap junction channels, are reduced in number or redistributed from intercalated disks (ID) to lateral cell borders in a variety of cardiac disease, especially in ischemic heart disease. The gap junction remodeling is considered to be arrhythmogenic. These findings will lead us to a new realm in the diagnostic of sudden death caused by coronary heart disease.

Key words: gap junctions, connexins, sudden death, coronary heart disease