法医学杂志

法医学杂志 ›› 2005, Vol. 0 ›› Issue (2): 104-106+.

• 论文 • 上一篇    下一篇

家兔急性心肌梗死CTnI免疫组织化学实验研究

贾建长,赵子琴,顾云菊,沈忆文,陈龙   

  1. 复旦大学上海医学院法医学系,复旦大学上海医学院法医学系,复旦大学上海医学院法医学系,复旦大学上海医学院法医学系,复旦大学上海医学院法医学系 上海200032 ,上海200032 ,上海200032 ,上海200032 ,上海200032
  • 发布日期:2005-04-25 出版日期:2005-04-28

Study of CTnI Immunohistochemistry on Acute Myocardial Infarction in Rabbits

JIA JIAN-ZHANG, ZHAO ZI-QIN,GU YUN-JU, ET AL. (DEPARTMENT OF FORENSIC MEDICINE, SHANGHAI MEDICAL COLLEGE, FUDAN UNIVERSITY, SHANGHAI, 200032,CHINA)   

  • Online:2005-04-25 Published:2005-04-28

被引次数

47

摘要： 目的研究CTnI诊断急性心肌梗死的法医病理学意义。方法结扎兔心脏左冠状动脉左旋支的左室支制作心肌梗塞动物模型。应用免疫组织化学法检测心肌梗塞区域CTnI的变化,与HE染色法进行比较。结果早期心肌梗塞组织,HE染色组尚未出现特征性梗死表现,免疫组织化学染色法可见CTnI分布以及含量变化,并且随着时间延长,变化区域扩大,且近心内膜心肌细胞同时出现变化。结论CTnI免疫组织化学检测可以应用于急性心肌梗死的诊断。

关键词: CTnI, 免疫组织化学, 急性心肌梗死, 病理学

Abstract: Objective To investigate the signification of CTnI in acute myocardial infarction Methods The model of myocardial infarction was established by ligating the left ventricle branch. Immunohistochemistry and image analysis were used to detect the change of CTnI in the model, and The sensitivity of immunohistochemistry and HE coloration were also compared. Results The acute myocardial infarction tissue showed obvious depletion of CTnI, there was no characterization of myocardial infarction in HE coloration. Conclusion CTnI is sensitive to diagnosis of acute myocardial infarction.

Key words: CtnI, immunohistochemistry, acute myocardial infarction, pathology