法医学杂志 ›› 2005, Vol. 0 ›› Issue (3): 223-225.

• 论文 • 上一篇    下一篇

脑损伤后COX-1和COX-2的表达

郭学荣,周亦武,马艺列,李振营,李欣,刘良   

  1. 广州市公安局广州经济技术开发区分局刑警大队,华中科技大学同济医学院法医学系,广州市公安局广州经济技术开发区分局刑警大队,广州市公安局广州经济技术开发区分局刑警大队,广州市公安局广州经济技术开发区分局刑警大队,华中科技大学同济医学院法医学系 广东广州510760华中科技大学同济医学院法医学系,湖北武汉430030 ,湖北武汉430030 ,广东广州510760 ,广东广州510760 ,广东广州510760 ,湖北武汉430030
  • 发布日期:2005-06-25 出版日期:2005-06-28

The Expression of COX-1 and COX-2 Following Brain Injuries

GUO XUE-RONG, ZHOU YI-WU, MA YI-LIE, ET AL. (FACULTY OF FORENSIC MEDICINE, HUAZHONG UNIVERSITY OF SCIENCE& TECHNOLOGY, WUHAN 430030,CHINA)   

  • Online:2005-06-25 Published:2005-06-28

摘要: 环加氧酶(cyclooxygenase,COX)是催化花生四烯酸(arachidonic,AA)合成前列腺素(prostaglandin,PG)的限速酶。后者在调节有丝分裂、凋亡、血管生成、血流动力学、继发性脑损伤及炎症反应等过程中发挥重要作用。COX有两种亚型:COX-1和COX-2。近年来研究证实,COX-1和COX-2在脑损伤过程中扮演了重要的角色。

关键词: 环加氧酶, 脑损伤, 损伤时间

Abstract: Cyclooxygenase (COX) is the obligate, rate- limiting enzyme for the conversion of arachidonic acid intoprostaglandins, which mediate mitogenesis, apoptosis, angiogenesis, blood flow, secondary injury, and inflammation.COX is consi st of 2 subtypes: COX- 1 and COX- 2. In recent years, there are a number of lines of evidencethat COX- 1 and COX- 2 play a important in role brain injuries.

Key words: cyclooxygenase, brain injury, post injury time