法医学杂志

法医学杂志 ›› 2008, Vol. 0 ›› Issue (5): 369-374+.

• 论文 • 上一篇    下一篇

谷氨酸受体基因单核苷酸多态性与精神分裂症的关联

李忠杰;王保捷;丁梅;庞灏;孙雪菲;杨俊;   

  1. 中国医科大学法医学院法医血清学教研室;
  • 发布日期:2008-10-25 出版日期:2008-10-28

The Association between Glutamate Receptor Gene SNP and Schizophrenia

LI ZHONG-JIE,WANG BAO-JIE,DING MEI,PANG HAO,SUN XUE-FEI,YANG JUN (DEPARTMENT OF FORENSIC SEROLOGY,SCHOOL OF FORENSIC MEDICINE,CHINA MEDICAL UNIVERSITY,SHENYANG 110001,CHINA)   

  • Online:2008-10-25 Published:2008-10-28

被引次数

18

摘要： 谷氨酸是人类神经系统中重要的兴奋性神经递质,通过与受体结合发挥生物学作用。当编码受体的基因异常时,可能导致精神疾病发生。本文通过回顾相关研究,发现诸如GRIN1、GRIN2B、GRM3等受体基因上的rs11146020、366C/G、rs1468412与精神分裂症相关联;同时也存在矛盾的研究结果,表明精神分裂症可能为多因素、多位点、多基因复杂遗传疾病。部分位点如GRIN2B上的366C/G、2664C/T,GRIK2上的rs1408766(C/T)的遗传多态性较好,可能成为法医学个人识别与亲权鉴定的新指标。该领域研究在司法精神病的鉴定工作中可能具有潜在的意义。

关键词: 司法精神病学, 精神分裂症, 综述[文献类型], 受体, 谷氨酸, 多态性, 单核苷酸

Abstract: Glutamate is a necessary excitatory neurotransmitter in human nervous system,which runs a biological function by binding with corresponding receptors. Psychiatric diseases occur when genes which encode receptors become dysfunctional. The authors have reviewed related literature and summarized the association between schizophrenia and glutamate receptor gene SNPs such as rs11146020 in GRIN1,366C/G in GRIN2B,and rs1468412 in GRM3,etc. Due to controversial results in various studies,it is hypothesized that schizophrenia are complicated polygenic inherited diseases. Some sites such as 366C/G,2664C/T and rs1408766(C/T) possess with valuable genetic polymorphisms and might potentially contribute to personal identification and paternity testing. Studies in this field may have a potential significance in forensic psychiatry practice.

Key words: forensic psychiatry, schizophrenia, review [publication type], receptor, glutamate, polymorphism, single nucleotide