法医学杂志

法医学杂志 ›› 2017, Vol. 33 ›› Issue (3): 232-235.DOI: 10.3969/j.issn.1004-5619.2017.03.003

• 论著 • 上一篇    下一篇

事件相关电位客观评估视敏度的法医学应用

罗  斌1，2，季萌萌1，孟欢欢1，陈溪萍1，陶陆阳1   

  1. （1. 苏州大学医学部法医学系，江苏 苏州 215123； 2. 安徽龙图司法鉴定中心，安徽 合肥 230000）
  • 发布日期:2017-06-25 出版日期:2017-06-28
  • 通讯作者: 陈溪萍，女，主任法医师，硕士研究生导师，主要从事法医临床学研究；E-mail：xipingchen@suda.edu.cn
  • 作者简介:罗斌（1990—），男，主要从事法医临床学鉴定与研究；E-mail：luobinmaibox@163.com
  • 基金资助:

    “十三五”国家重点研发计划资助项目（2016YFC080 0701）；国家自然科学基金资助项目（81373251）；国家高技术研究发展计划（863计划）项目（2015AA020503）

Forensic Application of Objective Assessment on Visual Acuity by ERP

LUO BIN1,2, JI MENG-MENG1, MENG HUAN-HUAN1, CHEN XI-PING1, TAO LU-YANG1   

  1. （1. Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China; 2. Anhui Longtu Judicial Identification Center, Hefei 230000, China）
  • Online:2017-06-25 Published:2017-06-28

摘要： 目的 研究不同视敏度水平的事件相关电位（event-related potential，ERP）成分特征，以期为视敏度的客观评定提供理论依据。 方法 选取16名被试进行单眼刺激。要求被试眼平视前方屏幕，注意屏幕中央的视觉刺激并对朝向不同的刺激进行计数。屏幕的中央会显示3种不同视敏度水平所对应的视标刺激图片，分别记录其ERP结果。 结果 （1）阈上视敏度水平一致刺激的P1振幅高于阈值、阈下视敏度水平一致刺激的P1振幅，阈值和阈下视敏度水平一致刺激的P1振幅差异无统计学意义，冲突刺激与一致刺激在3种视敏度水平的趋势类似。（2）阈上和阈值视敏度水平都出现了潜伏期在340~500 ms内的P300成分；阈下视敏度水平在相应的时间窗内无P300成分。3种视敏度水平的P300振幅差异有统计学意义，振幅由大到小分别为阈上、阈值、阈下视敏度水平。 结论 ERP技术可以成为法医学客观评定视敏度的新手段。

关键词: 法医学, 事件相关电位, 视敏度, P1, P300

Abstract: Objective To explore the composition characteristic of event related potential （ERP） in different visual acuity levels, and to provide theoretical basis for the objective assessment of visual acuity. Methods Monocular stimulus was performed on 16 selected subjects. The subjects were required to look straight at the screen ahead and count the amount of stimuli from different directions. The pictures of optotype stimulus which corresponding to three different visual acuity levels were showed in the center of the screen. The ERP results were recorded separately. Results （1） The P1 amplitudes of match stimuli recorded under the supra-threshold visual acuity level were higher than that of match stimuli recorded under the threshold and sub-threshold visual acuity levels. There was no significant difference between the P1 amplitudes of match stimuli recorded under the threshold and sub-threshold visual acuity levels. The tendency of conflict stimuli was similar to that of match stimuli under three visual acuity levels. （2） In the 340-500 ms post-stimulus range, P300 component was found under supra-threshold and threshold visual acuity levels; no P300 component was found in corresponding time window under sub-threshold visual acuity. The differences of P300 amplitudes among three visual acuity levels were statistically significant. The amplitudes from high to low were the supra-threshold, threshold and sub-threshold visual acuity levels. Conclusion ERP can be a potential new method for the objective assessment of visual acuity in forensic medicine.

Key words: forensic medicine, event-related potentials, visual acuity, P1, P300

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