Abstract: With the use of immunohistochemistry, the expression of basic fibroblast growth factor (bFGF) in earlyacute myocardial ischemia of rats was studied. It wasobserved that there was an initial (30min) rise in bFGFexpression in limited ischemic myocardium areas andperimyocardial ischemia areas. The grade of expressionof bFGF increased with the continuation of ischemia.The results of image analysis and statistical processsuggested that the expression of bFGF reach a high levelin ischemic myocardial areas after three hour's ofischemia, significantly higher than in control group andin group B1, but no significant difference in pericardialischemia areas and normal areas of the same group. Insummary, early acute myocardial ischemia is accompanied by rapid and prolonged increase in expression ofbFGF with characteristic spatial and temporal kinetic.This finding suggests that the immunohistochemicalstaining of bFGF provide objective morphologicevidence for the diagnosis of early myocardial ischemia.

Key words: acute myocardial ischemia, bFGF, immunohistochemistry