Experimental study on basic fibroblast growth factors in viral myocarditis

Abstract

Abstract: In order to know earlier pathological changes in myocarditis， 8 rats were inoculated with CVB3, and a model of viral myocarditis was built. The changes of basic fibroblast growth factors (bFGF) in acute viral myocarditis were observed by immunohistochemistry. It was found that the bFGF stain started to show positive at the third day after viral infection and that the positive degree increased afterwards. With normal HE staining, obvious lesion usually appeared under microscopy at least five days after infection. This suggests that the changes of bFGF in myocardium can be used for examination of early and light lesions of viral myocarditis.

Key words: viral myocarditis, basic fibroblast growth factor, immunohistochemistry

ZHA GUOQING;ET AL. (DEPARTMENT OF FORENSIC PATHOLOGY;SUN YAT－ SEN UNIVERSITY OF MEDICAL SCIENCES;GUNGZHOU 000). Experimental study on basic fibroblast growth factors in viral myocarditis[J]. , 2000, 0(4): 210-213+.

[1]	Xue-shi CHEN, Jun CHU, Li-jun YANG, Tao WANG, Lu-yang TAO. Application of Immunohistochemistry and Special Staining Technique in Forensic Traumatic Pathology Identification [J]. Journal of Forensic Medicine, 2021, 37(5): 666-672.
[2]	WU Mao-wang, SU Li, HE Fang, et al. Differential Expression of Integrin β1 in Two Brain Injury Models of Rats [J]. 法医学杂志, 2020, 36(4): 502-506.
[3]	CHEN Jing-wei, WANG Peng-fei, ZHANG Meng-zhou1，et al.. Relationship between Expression Changes of CB2R and Wound Age of Brain Contusion in Mice [J]. 法医学杂志, 2019, 35(2): 136-142.
[4]	ZHAO Jian-xin, JIN Xin, HUANG Jun-jie，et al.. Time-dependent Expression and Distribution of AChE during the Skin Incised Wound Healing in Mice [J]. 法医学杂志, 2019, 35(2): 143-148.
[5]	WEI SHU-RONG, CHEN XIN-SHAN, CHEN HUANG-FENG, ET AL.. Expression of Fas Protein of Myocardium in Dilated Cardiomyopathy [J]. , 2012, 28(4): 252-255.
[6]	YUAN XIANG-TIAN, PENG XUE, JIN ZHAN-FENG. Expression of FAPα and TGF-β1 in Sudden Deaths due to Acute Myocardial Ischemia [J]. , 2012, 28(1): 18-20.
[7]	WANG FU-YUAN, LI RU-BO, LIANG HONG-XIA, ET AL. Homer Protein Expression after Focal Brain Contusion in Rats [J]. , 2011, 27(6): 409-412.
[8]	PENG XUE, JIN ZHAN-FENG, SHAO HONG-JIANG, ET AL. Immunohistochemical Expression of HO-1 in Traumatic Human Brain Tissue [J]. , 2010, 26(5): 325-327,331.
[9]	XU HONG-FEI, CHEN JIAN-LEI, DA XU-PING, ET AL. Expression of CAR in Myocardial of Viral Myocarditis and Dilated Cardiomyopathy [J]. , 2010, 26(5): 328-331.
[10]	ZHU JIAN-HUA, HU YONG-LIANG, ZHANG WU, ET AL. Effects of Triptolide on Hypothalamic-pituitary-adrenal Axis of Rats [J]. , 2010, 26(4): 260-265.
[11]	HU LING;CHEN RUI;YU BIN-HUA;CHEN XIAO-GANG;LIU MIN(.WEST CHINA SCHOOL OF PRECLINICAL AND FORENSIC MEDICINE;SICHUAN UNIVERSITY;CHENGDU 00;CHINA;.GUANGDONG NANTIAN FORENSIC JUDICAL APPRAISAL INSTITUTE;SHENZHEN 0;CHINA;.DEPARTMENT OF FOR. In Vitro Study on bFGF Expression of Rat Astrocytes after Mechanical Injury [J]. , 2009, 0(5): 326-328+.
[12]	NING JUAN;LI YONG-HONG;ZHANG CHUN-BING(.DEPARTMENT OF FORENSIC PATHOLOGY;WANNAN MEDICAL COLLEGE;WUHU 00;CHINA;.FORENSIC EXPERTISE CENTER;EAST CHINA UNIVERSITY OF POLITICAL SCIENCE AND LAW;SHANGHAI 000;CHINA). Expression of Monocyte Chemoattractant Protein-1 in Sudden Death due to Viral Myocarditis and Its Medicolegal Significance [J]. , 2009, 0(5): 334-336.
[13]	GUO XIAO-CHONG;LI RU-BO;LIANG HONG-XIA;WANG FU-YUAN;WU XU (. DEPARTMENT OF FORENSIC PATHOLOGY;SCHOOL OF FORENSIC MEDICINE;CHINA MEDICAL UNIVERSITY;SHENYANG 000;CHINA;. KEY LAB OF LABORATORY TRANSGENIC ANIMAL OF LIAONING PROVINCE;DEPA. Expression of Matrix Metalloproteinase-3 after Brain Contusion in Rats [J]. , 2009, 0(1): 1-5.
[14]	WU XIAO-QIAO;LI YONG-HONG;ZHU XIAN;WU MAO-WANG;HU SHENG-MING (. THE THIRD DEPARTMENT OF MEDICINE;WANNAN MEDICAL COLLEGE;WUHU 00;CHINA;. INTENSIVE CARE UNIT;THE FIRST HOSPITAL OF HEFEI;HEFEI 000;CHINA;. HEFEI PUBLIC SECURITY BUREA. Expression of Fas Protein in Myocardiac Tissue of Viral Myocarditis and Dilated Cardiomyopathy [J]. , 2008, 0(6): 414-416+.
[15]	CHEN ZONG-YUN;WANG JING-YU;LI YONG-HONG (DEPARTMENT OF FORENSIC MEDICINE;WANNAN MEDICAL COLLEGE;WUHU 000;CHINA). The Expression of NGF after Rat Diffuse Axonal Injury [J]. , 2008, 0(3): 172-174.

Experimental study on basic fibroblast growth factors in viral myocarditis

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics