Abstract: Fibronectin is an important large adhesive glycoprotein of the extracellular matrix, which is alternatively spliced in three regions, designated EⅢA,EⅢB and ⅢCS respectively. ⅢCS contains two binding domains for a variety of cell surface and extracellular ligands. Through this multiplicity of adhesive activities, ⅢCS can fulfill key roles in a broad spectrum of physiological processes, such as cell spreading and migration, differentiation and embryogenesis, wound healing, malignant transformation and metastasis, etc. Here, we will discuss the structure, biological property, and function of Ⅲcs splicing variants and its forensic applications.

Key words: CS segment, alternative splicing, wound healing