Study on Determination and Distribution of GHB in Biological Fluids and Tissues of Acute Poisoned Rats

Abstract

Abstract: Objective To investigate the distribution of GHB in biological fluids and tissues and provide method and information for detcetion of GHB in Biological Fluids and Tissues Method The concentrations of GHB in Biological Fluids and Tissues were analyzed by gas chromatography-mass spectrometry; Two groups of rats were fed with 1000 mg/kg of GHB and were killed at 1 hour and 3 hours post dose, respectively. Results GHB concentrations of the administrated groups distributed in a degressive order of urine, stomach, blood, intestine, kidney, lung, spleen, heart, liver and brain. Conclusion Urine was the best specimen for the determination of GHB concentrations in biological fluids and tissues.

Key words: gamma-hydroxybutyric acid(GHB), GC/MS, concentration distribution, acute poisoned rats

LIU WEI;SHEN MIN;LIU XIAO-QIAN;SHEN BAO-HUA;XIANG PING (INSTITUTE OF FORENSIC SCIENCE;MINISTRY OF JUSTICE;P.R.CHINA;SHANGHAI 000;CHINA). Study on Determination and Distribution of GHB in Biological Fluids and Tissues of Acute Poisoned Rats[J]. , 2006, 0(1): 55-57.

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Study on Determination and Distribution of GHB in Biological Fluids and Tissues of Acute Poisoned Rats

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