Expression of Synaptophysin in Experimental Diffuse Brain Injury

›› 2007, Vol. 0 ›› Issue (1): 8-10+1.

Expression of Synaptophysin in Experimental Diffuse Brain Injury

FAN SHUAN-LIANG1,HUANG PING1,LIU YAN-FENG2,ZHANG PIN1,WANG ZHEN-YUAN1(1.DEPARTMENT OF FORENSIC SCIENCE,MEDICAL COLLEGE,XI′AN JIAOTONG UNIVERSITY,XI′AN 710061,CHINA;2.DEPARTMENT OF FORENSIC MEDICINE,MEDICAL COLLEGE OF BEIHUA UNIVERSITY,JILIN 132001,CHINA)

Online:2007-02-25 Published:2007-02-28

Abstract

Abstract: Object To investigate the changes in the expression_level of synaptophysin following diffuse brain injury(DBI) in rats and to correlate the changes of the synaptophysin expression_level with the post injury time interval.Methods Wister rats were used as a DBI model induced by Marmarou method.The changes of synaptophysin immunoreactivity on coronal sections of the rats sampled at different post-injury time intervals were used as a marker.The densitometry of the synaptophysin immunoreactivity was documented by imaging technique and analyzed by SPSS software.Results The expression_level of synaptophysin in DBI rats showed dynamic changes following DBI as well as during the repairing period.Conclusion The changes of synaptophysin level may be used as a marker for estimation of the post injury time interval in DBI.

Key words: synaptophysin, diffuse brain injury, post injury time interval

FAN SHUAN-LIANG;HUANG PING;LIU YAN-FENG;ZHANG PIN;WANG ZHEN-YUAN(.DEPARTMENT OF FORENSIC SCIENCE;MEDICAL COLLEGE;XI′AN JIAOTONG UNIVERSITY;XI′AN 00;CHINA;.DEPARTMENT OF FORENSIC MEDICINE;MEDICAL COLLEGE OF BEIHUA UNIVERSITY;JILIN 00;CHINA). Expression of Synaptophysin in Experimental Diffuse Brain Injury[J]. , 2007, 0(1): 8-10+1.

[1]	HUANG PING;LIU YAN-FENG;TUO YA;ZHANG PING;DING CUN-JING;FANG JIE;WANG ZHENG-YUAN;(.KEY LABORATORY OF ENVIRONMENT AND GENES RELATED TO DISEASES OF MINISTRY OF EDUCATION;XI′AN JIAOTONG UNIVERSITY;XI′AN 00;CHINA;.DEPARTMENT OF. Time-dependent Expression of Astroglial S100β Following Diffuse Brain Injury in Rats [J]. , 2006, 0(1): 4-6+99.
[2]	SU LI;ZHU XU-YANG;WANG JING-YU;ET AL. (DEPARTMENT OF FORENSIC MEDICINE;WANNAN MEDICAL COLLEGE;WUHU 00;CHINA). Induction of Hypoxia-inducible Factor-1(HIF-1) Following Diffuse Rats Brain Injury [J]. , 2005, 0(4): 244-245,248.
[3]	YU XIAO－ JUN;XIAO FEI;WU JIA－ WEN;ET AL.(.DEPARTMENT OF FORENSIC MEDICINE;MEDICAL COLLEGE OF BEIHUA UNIVERSITY;JILIN 00;. COLLEGE OF FORENSIC MEDICINE;WEST CHINA UNIVERSITY OF MEDICAL SCIENCES;CHENGDU 00) [. A study on pathological changes of closed diffuse brain injury in rats with H.E.,esterification－ silver stain and albumin immunohistochemical stain [J]. , 2001, 0(2): 69-73+7.

Expression of Synaptophysin in Experimental Diffuse Brain Injury

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