Relationship Between the Degradation of Myoglobin and Postmortem Interval

Abstract

Abstract: Objective To observe the degradation of myoglobin in skeletal and cardiac muscles after death and to explore its usefulness in estimation of postmortem interval.Methods Human skeletal and cardiac muscles were collected at 0,4,8,12,24,36,48,60,and 72 hours after death and stored at 25 ℃.The protein was extracted and examined and analyzed by Western blot and imaging technique.Results Myoglobin showed a continuously postmortem degradation in both skeletal and cardiac muscles.There was no observed difference in degradation between the two tissues.Conclusion Changes in myoglobin degradation could be a useful parameter for estimation of the postmortem interval.

Key words: human tissue, myoglobin, estimating of postmortem interval

BIAN JIE;SHEN YI-WEN;ZHAO ZI-QIN(SHANGHAI MEDICAL COLLEGE OF FUDAN UNIVERSITY;SHANGHAI 000;CHINA). Relationship Between the Degradation of Myoglobin and Postmortem Interval[J]. , 2007, 0(2): 90-91.

[1]	LI BIN;YAN HONG-TAO;CHEN WEI-JIE;WU JING-JIE;LIAO SHI-PING;LIAO ZHI-GANG (WEST CHINA SCHOOL OF BASIC MEDICINE AND FORENSIC SCIENCES OF SICHUAN UNIVERSITY;CHENGDU 00;CHINA). To Estimate Early Postmortem Interval by Investigating Changes of Rats′ Gastrocnemius Excitability [J]. , 2006, 0(2): 101-103.
[2]	LIU YING-CHUN;ZHU YOU-FA;WANG LI-XIN (. THE CENTRAL INSTITUTE OF JUDICIAL POLICE;BAODING 0000;CHINA;. MEDICAL COLLEGE;ZHEJIANG UNIVERSITY;HANGZHOU 00;CHINA;. YUHANG LINPING PEOPLE′S PROCURATORATE;HANGZHOU 00;CHINA). Immunohistochemistry on Myoglobin Renal Lesions in Human Kidney after Extensively Soft Tissues Injury [J]. , 2005, 0(4): 241-243.
[3]	MING MEI;MENG XIANG-ZHI(DEPARTMENT OF FORENSIC MEDICINE;SCHOOL OF MEDICINE;WUHAN UNIVERSITY;WUHAN00;CHINA). Immunohistochemical observation of heart-type fatty acid binding-protein in early myocardial ischemia [J]. , 2004, 0(1): 15-17+7.
[4]	LI GE;LU JUN-BAO;YAO QING-SONG;ET AL. (PROCURATORATE OF YUEXIU DISTRICT;GUANGZHOU 00;DE-PARTMENT OF FORENSIC PATHOLOGY;SUN YAT-SEN UNIVERSITY;GUANGZHOU 00;THE CRIMINAL SCIENCES RESEARCH INSTITUTE OF POLICE BUREAU OF GUANGZHOU;GUANGZHOU. Morphological changes of tissues after extensive soft tissue injury [J]. , 2003, 0(1): 18-21.
[5]	XU HONGBIN (DEPARTMENT OF BIOCHEMISLRY WANNANMEDICAL COLLEGE. WUHU 00). Comparative studiy on DNA abstraction of human tissues preseved by two different methods [J]. , 1998, 0(1): 18-19+6.
[6]	ZHOU WEI ET AL (DEPARTMENT OF FORENSIC PATHOLOGY;SUN YAT-SEN UNIVERSITY OF MEDICAL SCIENCESGUANGZHOU 00). Experimental study of myocardial myoglobin depletion induced by early myocardial infarction and coronary artery spasm [J]. , 1997, 0(3): 133-134+.
[7]	CHEN YIJIU;ZHAO ZIQIN;GU YUNJU;HUANG GUANGCUN(DEPARTMENT OF FORENSIC MEDICINE;SHANGHAI MEDICAL UNIVERSITY;SHANGHAI 000). Immunohistochemical study on myoglobin in electrocution [J]. , 1997, 0(1): 12-13+6.
[8]	GAO CAIRONG;WANG YINGYUAN;JI CHUNXUAN;ET AL (DEPARTMENT OF FORENSIC PATHOLOGY.SHANXI MEDICAL COLLEGE;SHANXI 0000). Ultrastructural histochemical and immunohistochemical study on myocardium of the rabbits in hemorrhagic sudden death [J]. , 1996, 0(2): 0-0.
[9]	吴军. Pathological,Physiological and Biological Changes of Crush Injury and Crush Syndrome (A Review) [J]. , 1996, 0(1): 0-0.
[10]	贾静涛. Pathological,Physiological and Biological Changes of Crush Injury and Crush Syndrome (A Review) [J]. , 1996, 0(1): 0-0.
[11]	向平. Pathological,Physiological and Biological Changes of Crush Injury and Crush Syndrome (A Review) [J]. , 1996, 0(1): 0-0.
[12]	MONG XIANGZHI;FU CUNJU;YIAN PING (DEPARTMENT OF FORENSIC MEDICINE;HUBEI MADICAL UNIVERSITY;HUBEI 00). Pathological,Physiological and Biological Changes of Crush Injury and Crush Syndrome (A Review) [J]. , 1996, 0(1): 0-0.
[13]	CHEN XINSHAN;HU JUN;QIN QISHENG;HUANG GUANGZHAO (DEPARTMENT OF FORENSIC PATHOLOGY;TONGJI MEDICAL UNIVERSILY;WUHAN;000). AN IMMUNOHISTOCHEMICAL STUDY OF MYOGLOBIN DEPLETION FROM MYOCARDI UM IN THE CASES OF SUDDEN MANHOOD EDATH SYNDROME [J]. , 1994, 0(2): 0-0.

Relationship Between the Degradation of Myoglobin and Postmortem Interval

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 13

Recommended Articles

Metrics