Abstract: Pathological changes due to intoxication of tetramethylenedisulphotetramine (TETS ) were studied. The resultsshowed that the signs of asphyxia were obvious, so were thecongestion and edema of the brain. The spotty and focalhemorrhages in brain stems, multiple myolysis of papillarymuscles and contractionbands necrosis of myocardium wereobserved occasionally. The main clinical symptom of intoxication was freqUunt clinic - tonic convulsions, which weresimilar to the grandma epilepsy. The poisoned died mainly in3 hours. The general poisoning symptoms, LD50, toxicological mechanism and medicolegal expertise were also reviewed.

Key words: tetramethylenedisulphotetramine, intoxication, rodenticide, pathological changes