A Color Test for Rapid Screening of Gamma-hydroxybutyric Acid (GHB) and Gamma-butyrolactone (GBL) in Drink and Urine

›› 2006, Vol. 0 ›› Issue (6): 424-427+.

A Color Test for Rapid Screening of Gamma-hydroxybutyric Acid (GHB) and Gamma-butyrolactone (GBL) in Drink and Urine

ZHANG SHAO-YU1, HUANG ZENG-PING2 (1.FUJIAN PUBLIC SECURITY COLLEGE, FUZHOU 350007, CHINA; 2.CENTER OF FORENSIC SCIENCE AND TECHNOLOGY OF FUJIAN PUBLIC SECURITY BUREAU,FUZHOU 350002, CHINA)

Online:2006-12-25 Published:2006-12-28

Abstract

Abstract: Objective A rapid color test for screening gamma-hydroxybutyric acid (GHB) and its precursor gamma-butyrolactone(GBL) was investigated in drink and urine samples. Methods In an acidic solution, GHB was converted to GBL, which reacted with hydroxylamine hydrochloride in presence of sodium hydroxide, forming hydroxamate. A purple complex was formed when hydroxamate reacted with ferric chloride in acidic condition. Results Detection limit concentrations of GHB in drinks were between 0.5-2 mg/mL, less than the popular abuse concentrations of GHB. This method was usable for urine, with detection limit concentration 0.5mg/mL. Interferences of common organic solvents and narcotics and depressants were surveyed. Conclusion This method is simple, safe, and rapid; it facilitates rapid screening of GHB and GBL in clinic and forensic laboratories.

Key words: gamma-hydroxybutyric acid(GHB), gamma-butyrolactone (GBL), color test, screening

ZHANG SHAO-YU;HUANG ZENG-PING (.FUJIAN PUBLIC SECURITY COLLEGE;FUZHOU 000;CHINA;.CENTER OF FORENSIC SCIENCE AND TECHNOLOGY OF FUJIAN PUBLIC SECURITY BUREAU;FUZHOU 000;CHINA). A Color Test for Rapid Screening of Gamma-hydroxybutyric Acid (GHB) and Gamma-butyrolactone (GBL) in Drink and Urine[J]. , 2006, 0(6): 424-427+.

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A Color Test for Rapid Screening of Gamma-hydroxybutyric Acid (GHB) and Gamma-butyrolactone (GBL) in Drink and Urine

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