Distribution of tryptophan hydroxylase Gene-T457C Locus Polymorphism in Han Ethnic Group in Northern China

Abstract

Abstract: Objective To study the distribution of the tryptophan hydroxylase(TPH) gene-T457C locus polymorphism in Han ethnic group in northern China and to find its applicable value in forensic science. Methods Genomic DNA samples, extracted from 180 unrelated individuals in northern Chinese Han population, were analyzed by PCR-RFLP. Results The discrimination power (DP) value and the power of exclusion (PE) value of the TPH gene-T457C locus were 0.624 and 0.187, respectively. The allele frequency showed significant difference from that of French people (P=0.04). Conclusion Polymorphism of the TPH gene-T457C locus could show ethnic and regional differences. It has a potential to be used in forensic science.

Key words: forensic science, tryptophan hydroxylase (TPH), single nucleotide polymorphism

GUAN HONG-YU;WANG BAO-JIE;DING MEI;PANG HAO;WANG BIN;LU HONG-TAO;XING JIA-XIN;YI JIN-FENG;LI CHUN-MEI (SCHOOL OF FORENSIC MEDICINE;CHINA MEDICAL UNIVERSITY;SHENYANG 000;CHINA). Distribution of tryptophan hydroxylase Gene-T457C Locus Polymorphism in Han Ethnic Group in Northern China[J]. , 2007, 0(6): 444-445.

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Distribution of tryptophan hydroxylase Gene-T457C Locus Polymorphism in Han Ethnic Group in Northern China

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