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28 October 2008, Volume 24 Issue 5 Previous Issue    Next Issue
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The Correlativity between the Threshold Acquired with ASSR and PTA YANG XIAO-PING;FAN LI-HUA;ZHOU XIAO-RONG (SHANGHAI KEY LABORATORY OF FORENSIC MEDICINE;INSTITUTE OF FORENSIC SCIENCE;MINISTRY OF JUSTICE;P.R.CHINA;SHANGHAI 000;CHINA) 2008, 0(5): 321-324.  Abstract ( 2154 )   Objective To explore the correlativity between the thresholds acquired with auditory steady-state responses(ASSR) and pure tone audiometry(PTA). Methods Eighty-six subjects with normal and abnormal hearing(172 ears) were tested with ASSR and PTA at 500,1 000,2 000,4 000 Hz to get the thresholds of ASSR(single frequency) and PTA. Correlation analysis were done between the thresholds acquired with ASSR and PTA at different frequency(500,1 000,2 000,4 000 Hz) for each different hearing loss degree(≤20,21-39,40-59,60-79,≥80 dB). Results At each frequency,there was a close correlativity between the thresholds acquired with ASSR and PTA. The rectified threshold of ASSR and PTA at different frequency and hearing loss degree had been obtained. Conclusion The rectified ASSR threshold could be applied as an objective method for evaluating hearing loss to distinguish malingering deafness in the practice of forensic medicine. Related Articles | Metrics

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Changes of Phospho-JNK Expression during the Skin Burned Wound Healing XIONG CHANG-YAN;GUAN DA-WEI;LIU ZHI-HUI;ZHEN BO;ZHAO RUI;ZHU BAO-LI (. SCHOOL OF FORENSIC MEDICINE;CHINA MEDICAL UNIVERSITY;SHENYANG 000;CHINA;. DEPARTMENT OF BURN;LIAONING PROVINCIAL CORPS HOSPITAL;CHINESE PEOPLE′S ARMED POLICE FORCES;SHENYAN 2008, 0(5): 325-326+.  Abstract ( 1732 )   Objective To observe the changes of expression of phosphorylation c-Jun NH2-terminal kinase(p-JNK) during the skin burned wound healing in patients and discuss the molecular mechanism of burned wound healing. Methods The staining intensity and distribution of p-JNK were detected by immunohistochemistry and routine histology in burned skin samples of 12 patients and normal skin samples of 12 control subjects. Results In normal skin,the positive signals of p-JNK were mostly localized in basal layer cells of the epidermis,with a positive rate of (8.8±1.3)%. In the burned group,the positive signals of p-JNK were mainly localized in the epidermal cells and some inflammatory cells,with a significantly higher positive rate of (31.2±3.3)% than the normal group(P<0.01). Conclusion The changes of p-JNK expression after skin burned might correlate with wound healing. Related Articles | Metrics

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Changes of RyR_2 mRNA Expression in Rats Suffering from Acute Myocardial Ischemia JIE YA;ZHU SHAO-HUA;JIANG YAN-WEI;ZHANG LEI;FAN FAN (. DEPARTMENT OF FORENSIC MEDICINE;TONGJI MEDICAL COLLEGE;HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY;WUHAN 000;CHINA;. TIANJIN INSTITUTE OF CRIMINAL SCIENCE AND TECHNOLOGY;TIANJIN 00;CH 2008, 0(5): 327-329+.  Abstract ( 2056 )   Objective To investigate the changes of ryanodine receptor 2(RyR2) mRNA expression in rats suffering from acute myocardial ischemia. Methods SD rats were divided randomly into normal control group,myocardial ischemia group and sudden death group. The models of myocardial ischemia and sudden cardiac death were induced by intraperitoneal injection of hypophysine. The changes of RyR2 mRNA expression in cardiac sarcoplasmic reticulum(SR) of rats suffering from myocardial ischemia were detected by fluorescent RT-PCR technique. Results The levels of RyR2 mRNA in the myocardial ischemia group and sudden death group were significant lower than those in the control group(P<0.05). Conclusion Myocardial ischemia may induce down-regulation of cardiac SR RyR2 mRNA expression. Related Articles | Metrics

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DNA Polymorphism Detection of Cannabis Using Amplified Fragment Length Polymorphism GUO JIA;PEI LI;PENG JIAN-XIONG;ZHAI HONG;ZHANG GUI-QIN;JIE QIN;TU ZHENG (. CHINESE PEOPLE′S PUBLIC SECURITY UNIVERSITY;BEIJING 000;CHINA;. INSTITUTE OF FORENSIC SCIENCE;MINISTRY OF PUBLIC SECURITY;P.R.C;BEIJING 000;CHINA;. CHINA AGRICULT 2008, 0(5): 330-332.  Abstract ( 1744 )   Objective To screen the AFLP primers with good diversity to distinguish various species of Cannabis. Methods The AFLP was used to analyze the genetic diversity of 12 species of Cannabis using 55 primer combinations. Results A total of 285 AFLP bands were obtained using five primer combinations with better diversity,among which 99 bands were polymorphic and 10 bands were special,with 47-76 bands amplified in each pair of primers. Conclusion AFLP may has good resolution in the diversity study of Cannabis. It may provide an essential basis for further study of the genetic diversity of Cannabis. Related Articles | Metrics

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The Association of Tyrosine Hydroxylase Gene Polymorphism with Mental Disorder YU JIAN;PANG HAO;WANG BAO-JIE (. SCHOOL OF FORENSIC MEDICINE;CHINA MEDICAL UNIVERSITY;SHENYANG 000;CHINA;. TRAFFIC POLICE DEPARTMENT;SHENYANG PUBLIC SECURITY BUREAU;SHENYANG 000;CHINA) 2008, 0(5): 333-335.  Abstract ( 1948 )   Objective To evaluate the relationship between the tyrosine hydroxylase(TH) gene and mental disorder by comparing the two TH gene SNP points(extron 3 and intron 9) of patients with mental disorders and normal human. Methods DNA extracted from specimens of patients and normal subjects were quantified by using Real-time PCR. Results (1) G334A distribution was: G=0.133,A=0.867 in patients with schizophrenia,G=0.116,A=0.884 in patients with depression,and G=0.214,A=0.786 in normal group. (2) C5162G distribution was: C=0.962,G=0.038 in patients with schizophrenia,C=0.959,G=0.041 in patients with depression,and C=0.961,G=0.039 in normal group. Conclusion There are statistically significant differences in G334A locus between normal people and patients with mental disorders,but no statistically significant differences in C5162G locus. Related Articles | Metrics

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Analysis of 72 Affective Disorder Cases in Forensic Psychiatric Expertise MA BIN-FANG;ZHOU LING-ER;QI YONG-HUA;KANG MING (. ANKANG HOSPITAL;HANGZHOU PUBLIC SECURITY BUREAU;HANGZHOU;CHINA;. THE SEVENTH PEOPLE′S HOSPITAL OF HANGZHOU;HANGZHOU 00;CHINA) 2008, 0(5): 336-338.  Abstract ( 2011 )   Objective To explore criminal characteristics of patients with affective disorder. Methods Analysis was conducted in 72 cases of affective disorder diagnosed in Ankang Hospital,Public Security Bureau of Hangzhou,from 2000 to 2004. Results There was a correlation between outbreak of the affective disordered and frequency of committing crime. There was a significant difference between the mania and the depression(P<0.01) with respect to harmful behavior. The criminal behavior characteristics of patients with affective disorder were different from that of the schizophrenia,with more realistic and less pathologic intention. Conclusion Recurrent attacks are warning signs for affective disorder patients committing crime. The criminal behavior characteristics of the affective disorder are different from that of the schizophrenia,probably because of the differences in etiological factor,development,symptom,and severity of the disorders. Related Articles | Metrics

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Study of Mental Disorder Due to Brain Damage TAN CHENG-WEN;WANG ZHEN-ZHI;XU JIN-YING;SUN ZHI-LIN;WANG LIN;CHAI BIN (PSYCHIATRIC HOSPITAL OF HUAINAN CITY;HUAINAN 0;CHINA) 2008, 0(5): 339-341.  Abstract ( 2065 )   Objective To study the incidence rate,pattern and affective factors of mental disorder due to brain damage. Methods According to CCMD-2-R,388 subjects with traumatic brain damage in the Psychiatric Hospital of Huainan city within last 5 years were assessed by three psychiatrists 6 months to 1 year after brain injury. Results (1) 74.2% of the mental disordered due to brain injury have intellectual impairment,most of them is mild; (2)The intracranial hematoma,brain stem injury,brain injury extent,GCS,complicated mental disorder,and education have great effect on intellectual impairment; (3) There is an intimate relationship between the intellectual impairment and the brain stem injury,intracranial hematoma,GCS,brain injury extent,and unconsciousness time. There is an intimate relationship between the mental symptom and the brain injury extent,contusion and laceration of brain,frontal lobe injury,and intracranial hematoma. There is also an intimate relationship between the personality change and the frontal lobe injury,unfolding brain case treatment,and intracranial hematoma. Conclusion To assess over-all mental disorder should rely on the characteristics of craniocerebral injuries. Related Articles | Metrics

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Characteristics of Death Cases Caused by Road Traffic Accident in Shenzhen XU DAI-HUA;GUO SI-YUN;LI ZHI-HONG (. NANTIAN EXPERT TESTIMONY FIRM OF GUANGDONG;SHENZHEN 0;CHINA;. TRAFFIC DEPARTMENT OF PUBLIC SECURITY BUREAU OF SHENZHEN;SHENZHEN 00;CHINA) 2008, 0(5): 342-343+.  Abstract ( 2299 )   Objective By summarize the characteristics of death cases caused by road traffic accident,to provide information and data for prevention of traffic accident. Methods To retrospectively analyze 4 148 death cases caused by road traffic accident in Shenzhen. The characteristics studied include the age and sex of the dead,the cause of death,time and place of the accidents and vehicle types,etc. Results The death was mainly male and the proportion of male to female is 2.45∶1; the accidents mainly occured in 6:00-8:00 and 18:00-2:00; 72% of the accidents took place on the main suburban roads. The proportions for each traffic modes of the death were: 44% of walking,19% of bike,15% of motorbike. Most traffic accidents were induced by truck,83.2% of the death causations were severe head injury and 13.3% were complex injuries. Conclusion The death cases of road-traffic accident in Shenzhen has obvious characteristic and maybe is preventible. Related Articles | Metrics

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Epidemiological Features of the Injured in Road Traffic Accidents in Shanghai FAN LI-HUA;XIA WEN-TAO;SHEN JIA-JIAN;CHEN XIN;ZHAO ZI-QIN;HOU XIN-YI (. SHANGHAI KEY LABORATORY OF FORENSIC MEDICINE;INSTITUTE OF FORENSIC SCIENCE;MINISTRY OF JUSTICE;P.R.CHINA;SHANGHAI 000;CHINA;. INSTITUTE OF FORENSIC SCIENCE;SHANGHAI PUBLIC 2008, 0(5): 344-348.  Abstract ( 1917 )   Objective To provide reference data for enacting and revising the laws and regulations of the disability expertise. Methods The epidemiological features of the disabled caused by road traffic accident in Shanghai during 2005 were retrospectively analyzed. Results The most common injuries were in extremities(53.3%),followed by head(23.3%),spine(9.7%),thorax(5.8%),and abdomen(4.4%). The cumulative incidence rate of disability due to traffic injuries was 414.8 cases per 100 000 inhabitants,higher for men(505.7/100 000) than women(318.7/100 000). The highest incidence rate of disability was between age 35 and 59(538.2/100 000). The most disabled was bicyclist,followed by pedestrian. Conclusion The incidence rate of disability among 35～59 age group was the highest in Shanghai during 2005. It has resulted in loss of labor force with a negative effect on the economic development. Related Articles | Metrics

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Eyeball Structure Changes in High Myopic Patients and Their Significance for Forensic Assessment LIU YI-CHANG;XIA WEN-TAO;ZHOU XING-TAO;LIU RUI-JUE;BIAN SHI-ZHONG;YING CHONG-LIANG;ZHU GUANG-YOU (. DEPARTMENT OF FORENSIC MEDICINE;MEDICAL COLLEGE OF SOOCHOW UNIVERSITY;SUZHOU;CHINA;. SHANGHAI KEY LABORATORY OF FORENSIC MEDICINE;INSTIT 2008, 0(5): 356-360.  Abstract ( 1663 )   There are irreversible eyeball structural changes in high myopic patients. These changes include axial length,corneal radius,anterior chamber depth,fundus degeneration,macula thickness,etc. There is a close relationship between the damage degree of visual function and these changes. The incidence of complications,such as vitreous opacity,posterior vitreous detachment,cataract,glaucoma,posterior staphyloma and retina detachment,is also highly related to the myopia diopter. More and more researches have indicated that the myopia diopter and the level of visual function are affected by multiple factors. It is promising to detect all of these changes by different kinds of methods,and to assess visual function through these changes. By clarifying these changes,it is also useful to distinguish traumatic damage from disease to provide evidence for forensic assessment of eye injuries. Related Articles | Metrics

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Sudden Infant Death Syndrome(SIDS) and Its Forensic Investigation LI LING;HUANG GUANG-ZHAO;SHEN YI-WEN;ZHOU LAN;LIU-LIANG;DAVID FOWLER;(. OFFICE OF THE CHIEF MEDICAL EXAMINER;STATE OF MARYLAND;BALTIMORE 0;UNITED STATES;. DEPARTMENT OF FORENSIC MEDICINE;TONGJI MEDICAL COLLEGE;WUHAN 000;CHINA;. DEP 2008, 0(5): 361-364.  Abstract ( 1816 )   During the past two decades tremendous efforts have been made by the medical community,especially in the fields of forensic medicine and pediatrics,to better understand the etiology,epidemiology and pathophysiology of SIDS. There have been many SIDS reports from developed countries,but few from developing Asian countries. Despite a recent significant decrease in the incidence of SIDS in many developed countries,SIDS continues to be the most common cause of post-neonatal infant death in these countries. This article analyzes the SIDS data(1990-2006) from the Office of the Chief Medical Examiner for the State of Maryland,USA,along with review of the literature with regard to the history,epidemiological and pathophysiological characteristics of SIDS,as well as the recent advances in SIDS research. The changing trends in the diagnosis of SIDS and current challenges to its forensic investigation are also discussed. Related Articles | Metrics

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The Development and Application of Lie Detection in Forensic Science WANG LU;YANG LING;GE YAN;CAI JI-FENG;CHANG YUN-FENG;LAN LING-MEI (. THIRD XIANG-YA HOSPITAL;CENTRAL SOUTH UNIVERSITY;CHANGSHA 00;CHINA;. DEPARTMENT OF FORENSIC MEDICINE;SCHOOL OF BASIC MEDICAL SCIENCES;CENTRAL SOUTH UNIVERSITY;CHANGSHA 00 2008, 0(5): 365-368.  Abstract ( 1720 )   Lie detection technology has been applied increasingly to investigate and solve criminal cases. This article explores the evolvement of lie detection technology in the ancient times and the application of the psychological and physiological parameters which have become more accurate with the introduction of modern polygraph. The cognitive exploration and the application of Event Related Potentials(ERPs),functional Magnetic Resonance Imaging(fMRI),and Event-Related functional Magnetic Resonance Imaging(E-R fMRI) have made detection technology focus on the brain activities,which produce more objective results by tracing the original state of lying. In summary,this article describes different types of lie detections,simple and complex,their working principles,the latest development,and the prospect of their application in forensic science. Related Articles | Metrics

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The Association between Glutamate Receptor Gene SNP and Schizophrenia LI ZHONG-JIE;WANG BAO-JIE;DING MEI;PANG HAO;SUN XUE-FEI;YANG JUN (DEPARTMENT OF FORENSIC SEROLOGY;SCHOOL OF FORENSIC MEDICINE;CHINA MEDICAL UNIVERSITY;SHENYANG 000;CHINA) 2008, 0(5): 369-374+.  Abstract ( 1965 )   Glutamate is a necessary excitatory neurotransmitter in human nervous system,which runs a biological function by binding with corresponding receptors. Psychiatric diseases occur when genes which encode receptors become dysfunctional. The authors have reviewed related literature and summarized the association between schizophrenia and glutamate receptor gene SNPs such as rs11146020 in GRIN1,366C/G in GRIN2B,and rs1468412 in GRM3,etc. Due to controversial results in various studies,it is hypothesized that schizophrenia are complicated polygenic inherited diseases. Some sites such as 366C/G,2664C/T and rs1408766(C/T) possess with valuable genetic polymorphisms and might potentially contribute to personal identification and paternity testing. Studies in this field may have a potential significance in forensic psychiatry practice. Related Articles | Metrics

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Recent Advances of Amplified Fragment Length Polymorphism and Its Applications in Forensic Botany LI CHENG-TAO;LI LI (. SHANGHAI KEY LABORATORY OF FORENSIC MEDICINE;INSTITUTE OF FORENSIC SCIENCE;MINISTRY OF JUSTICE;P.R.CHINA;SHANGHAI 000;CHINA;. SCHOOL OF LIFE SCIENCES;FUDAN UNIVERSITY;SHANGHAI 00;CHINA) 2008, 0(5): 375-377.  Abstract ( 1966 )   Amplified fragment length polymorphism(AFLP) is a new molecular marker to detect genomic polymorphism. This new technology has advantages of high resolution,good stability,and reproducibility. Great achievements have been derived in recent years in AFLP related technologies with several AFLP expanded methodologies available. AFLP technology has been widely used in the fields of plant,animal,and microbes. It has become one of the hotspots in Forensic Botany. This review focuses on the recent advances of AFLP and its applications in forensic biology. Related Articles | Metrics