法医学杂志 ›› 2022, Vol. 38 ›› Issue (2): 254-257.DOI: 10.12116/j.issn.1004-5619.2020.300901

• 案例分析 • 上一篇    下一篇

29例磷化氢中毒者体内总磷化氢分布以及磷化氢中毒特征分析

严慧1(), 杜猛2, 乔正1, 向平1, 沈保华1, 沈敏1, 刘伟1()   

  1. 1.司法鉴定科学研究院 上海市法医学重点实验室 司法部司法鉴定重点实验室 上海市司法鉴定专业技术服务平台,上海 200063
    2.上海市公安局嘉定区分局刑事科学技术研究所,上海 201800
  • 收稿日期:2020-09-21 发布日期:2022-04-25 出版日期:2022-04-28
  • 通讯作者: 刘伟
  • 作者简介:刘伟,女,主任法医师,主要从事法医毒物学研究;E-mail:liuw@ssfjd.cn
    严慧(1984—),女,副研究员,主要从事法医毒物学研究;E-mail:yanh@ssfjd.cn
  • 基金资助:
    上海市自然科学基金资助项目(19ZR1458800);司法部司法鉴定重点实验室资助项目;上海市法医学重点实验室资助项目(21DZ2270800);上海市司法鉴定专业技术服务平台资助项目(19DZ2290900)

Analysis of the Distribution of Total Phosphine and the Characteristics of Phosphine Poisoning in 29 Victims

Hui YAN1(), Meng DU2, Zheng QIAO1, Ping XIANG1, Bao-hua SHEN1, Min SHEN1, Wei LIU1()   

  1. 1.Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China
    2.Institute of Criminal Science and Technology, Jiading Branch of Shanghai Public Security Bureau, Shanghai 201800, China
  • Received:2020-09-21 Online:2022-04-25 Published:2022-04-28
  • Contact: Wei LIU

摘要: 目的

对磷化氢中毒者体内总磷化氢的分布进行研究,总结归纳该类中毒案件的特征。

方法

采用顶空气相色谱-质谱法对16起磷化氢中毒案件中29例中毒者生物样品中的磷化氢及代谢物进行定性和定量分析。

结果

29例中毒者中有5例为口服磷化铝中毒,24例为吸入磷化氢气体中毒。23例中毒者的体内检材中检出磷化氢代谢物,血液中总磷化氢质量浓度为0.5~34.0 μg/mL,磷化氢中毒死者肝组织中总磷化氢质量分数最高达71.0 μg/g。另有6例生还的中毒者血液中未检出磷化氢,可能与其磷化氢暴露量较小、血液采样不及时有关。

结论

口服磷化铝致死者血液和组织中总磷化氢浓度较高,吸入磷化氢中毒死亡案件呈现磷化氢气体暴露时间长、多次暴露、年龄易感等特点。

关键词: 法医毒理学, 中毒, 磷化氢类, 磷化铝, 代谢物, 组织分布, 案例分析

Abstract: Objective

To study the distribution of total phosphine in phosphine poisoning victims and summarize the characteristics of phosphine poisoning cases.

Methods

The phosphine and its metabolites in the biological samples of 29 victims in 16 phosphine poisoning cases were qualified and quantified by headspace gas chromatography-mass spectrometry.

Results

Five victims among 29 were poisoned by ingestion of aluminium phosphide and 24 by inhalation of phosphine gas. Phosphine metabolites were detected in the biological samples of 23 victims, and the concentrations of total phosphine in blood ranged 0.5-34.0 μg/mL. The total concentration of phosphine in liver tissue was up to 71.0 μg/g. Phosphine was not detected in the blood of the other six survived victims, which may be related to the small amount of phosphine exposure and the delay in blood sampling.

Conclusion

The total concentration of phosphine in blood and tissues caused by aluminum phosphine ingestion is higher than that caused by phosphine gas inhalation. The death cases of phosphine inhalation are characterized by long exposure time, repeated exposures and age susceptibility.

Key words: forensic toxicology, poisoning, phosphines, aluminium phosphide, metabolite, tissue distribution, cases analysis

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