法医学杂志

法医学杂志 ›› 2015, Vol. 31 ›› Issue (6): 466-469.DOI: 10.3969/j.issn.1004-5619.2015.06.013

• 综述 • 上一篇    下一篇

轻度创伤性脑损伤脑脊液及血液生物标记物研究进展

黄  雯1，李上勋2，李学建1，徐宏云2   

  1. 1. 武汉市公安局武昌区公安分局，湖北 武汉 430060； 2. 湖北省公安厅，湖北 武汉 430070
  • 发布日期:2015-12-25 出版日期:2015-12-28
  • 作者简介:黄雯（1984—），女，主检法医师，主要从事法医现场勘查及脑损伤研究；E-mail：huangwen124@sohu.com

Advances in Biomarkers of Mild Traumatic Brain Injury in Cerebrospinal Fluid and Blood

HUANG WEN1, LI SHANG-XUN2, LI XUE-JIAN1, XU HONG-YUN2   

  1. 1. Wuchang Public Security Sub-bureau, Wuhan Public Security Bureau, Wuhan 430060, China; 2. Hubei Province Public Security Department, Wuhan 430070, China
  • Online:2015-12-25 Published:2015-12-28

摘要： 轻度创伤性脑损伤（mild traumatic brain injury，MTBI）被认为是轻度脑损伤导致的短暂意识丧失和精神改变，但有时也会导致持久性、进行性的临床症状。MTBI可引起神经系统结构损伤及相应的体液生物标记物改变，但有关其严重程度及个体易感性与意识障碍持续时间的关联程度研究不足，同时，一次打击后脑损伤程度也缺乏可靠的评估方法。本文综述了与TBI有关的脑脊液及血液生物标记物，探讨这些标记物在MTBI诊断中的应用现状及研究前景，为法医学及临床医学中脑损伤的诊断及评估提供参考依据。

关键词: 法医病理学, 脑损伤, 综述[文献类型], 脑脊液, 生物学标记

Abstract: Mild traumatic brain injury （MTBI） is defined as a mild brain trauma resulting in a short loss of consciousness and alteration of mental status. It may also occasionally develop persistent and progressive symptoms. It has been confirmed that MTBI causes changes of anatomic structures in central nervous system and biomarkers in the body fluid. However, there is no sufficient research on relevance among threshold for the brain injury, individual vulnerability and duration of disturbance of consciousness. Furthermore, there are no reliable diagnostic methods to establish whether a blow to the head is sufficient to cause the brain injury. This review provides references for biomarkers in cerebrospinal fluid and blood associated with TBI. It also provides application status and potential prospects for further assessment and diagnosis of MTBI.

Key words: forensic pathology, brain injuries, review [publication type], cerebrospinal fluid, biological markers

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