法医学杂志

法医学杂志 ›› 2016, Vol. 32 ›› Issue (1): 40-44.DOI: 10.3969/j.issn.1004-5619.2016.01.009

• 论著 • 上一篇    下一篇

外周血IL-17蛋白表达与双相躁狂破坏攻击行为的相关性

李豪喆1，4，洪  武1，汪作为1，3，苑成梅1，李则挚1，黄  佳1，张  晨1，李宁宁1，林治光2，方贻儒1   

  1. （1. 上海交通大学医学院附属精神卫生中心 上海市精神疾病临床医学中心心境障碍科，上海 200030； 2. 上海交通大学医学院附属精神卫生中心生化研究室，上海 200030； 3. 上海市虹口区精神卫生中心，上海 200083； 4. 司法部司法鉴定科学技术研究所 上海市法医学重点实验室，上海 200063）
  • 发布日期:2016-02-25 出版日期:2016-02-28
  • 通讯作者: 洪武，女，副主任医师，博士，主要从事心境障碍的基础和临床研究；E-mail：drhongwu@126.com
  • 作者简介:李豪喆（1989—），男，博士，主要从事心境障碍的基础和临床研究及司法精神病学研究；E-mail：lihaozhe_kira@ outlook.com
  • 基金资助:

    国家自然科学基金资助项目（91232719）；“十二五”国家科技支撑计划项目（2012BAI01B04）；国家临床重点专科—上海市精神卫生中心（卫生部医政司2011-873）；上海市卫生局科研项目（20134071）；上海市精神卫生中心院级课题（2011-YJ-06）；上海市法医学重点实验室开放课题（KF1507）；中央级科研院所科研专项（GY2016Z-3）；上海市精神疾病临床医学中心（2014）

Correlation between Expression of Peripheral IL-17 Protein and Aggression of Bipolar Mania

LI HAO-ZHE1,4, HONG WU1, WANG ZUO-WEI1,3, YUAN CHENG-MEI1, LI ZE-ZHI1, HUANG JIA1, ZHANG CHEN1, LI NING-NING1, LIN ZHI-GUANG2, FANG YI-RU1   

  1. （1. Division of Mood Disorders, Shanghai Clinical Center for Mental Disorders, Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China; 2. Department of Biochemistry, Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China; 3. Hongkou District Mental Health Center, Shanghai 200083, China; 4. Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China, Shanghai 200063, China）
  • Online:2016-02-25 Published:2016-02-28

摘要： 目的 探讨白介素17（interleukin-17，IL-17）在外周血的蛋白表达水平及其与双相躁狂破坏攻击行为的关系。 方法 纳入符合DSM-IV-TR诊断标准的双相躁狂患者36名，予以锂盐联合喹硫平治疗，同时纳入性别和年龄匹配的正常对照36名。采用酶联免疫吸附法（ELISA）检测两组基线及第2、4、8周末IL-17水平。 结果 双相躁狂组基线、第2周末、第4周末的IL-17蛋白水平高于对照组，而第8周末与对照组差异无统计学意义（P>0.05）。双相躁狂组Young氏躁狂量表（Young Mania Rating Score，YMRS）总分以及YMRS第9项破坏攻击行为评分在第2、4、8周末均显著低于基线水平（P<0.05），且基线IL-17蛋白水平与该两项分呈正相关（P<0.05）。 结论 双相躁狂可能与外周血IL-17蛋白表达水平上调相关，同时基线期IL-17蛋白表达水平与双相躁狂严重程度，尤其是攻击破坏行为的严重程度相关。

关键词: 司法精神病学, 双相情感障碍, 白介素17, 攻击行为

Abstract: Objective To explore the correlation between the interleukin-17 （IL-17） level of peripheral blood and aggression of bipolar mania. Methods Thirty-six patients of bipolar mania were selected as experimental group by DSM-Ⅳ-TR and received treatment with quetiapine and lithium. Thirty-six healthy volunteers with similar age and gender were selected as control group. The level of IL-17 at baseline in each group and the level of IL-17 in the experimental group after treatment for 2, 4 and 8 weeks were detected by ELISA. Results The level of IL-17 in experimental group at baseline, after treatment for 2 and 4 weeks were all significantly higher than that in control group. After 8 weeks treatment, there was no significant difference between the two groups （P>0.05）. After 2, 4 and 8 weeks treatment, the total score and aggression score of Young Mania Rating Score （YMRS） were significantly lower than the baseline level （P<0.05）. In experimental group, the level of IL-17 was positively correlated with the two scores of YMRS at baseline （P<0.05）. Conclusion Bipolar mania may be related to the up-regulation of IL-17. The level of IL-17 is related to the severity of manic symptoms at baseline, especially aggression symptom.

Key words: forensic psychiatry, bipolar disorder, interleukin-17, aggression

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