法医学杂志

法医学杂志 ›› 2020, Vol. 36 ›› Issue (3): 326-332.DOI: 10.12116/j.issn.1004-5619.2020.03.006

• 论著 • 上一篇    下一篇

脑外伤所致精神障碍者冲动控制能力及ERP特征

宋宏飞1， 邓茜1， 杨宁1， 郝博1， 胡喻博1， 时燕薇1，2， 薛丽1，2， 赵虎1，2   

  1. 1. 中山大学中山医学院法医学系，广东 广州 510080； 2. 广东省法医学转化医学工程技术研究中心，广东 广州 510080
  • 发布日期:2020-06-25 出版日期:2020-06-28
  • 通讯作者: 薛丽，女，副研究员，主要从事法医精神病学研究和检案；E-mail：ellen1136@163.com 赵虎，男，教授，博士研究生导师，主要从事法医精神病学与法医临床学教学、科研和检案；E-mail：zhaohu3@mail.sysu.edu.cn
  • 作者简介:宋宏飞（1992—），女，苗族，硕士研究生，主要从事法医精神病学研究；E-mail：fayishf@163.com
  • 基金资助:
    国家自然科学基金面上资助项目（81871535）

Impulse Control and ERP Characteristics of Patients with Mental Disorder Caused by Traumatic Brain Injury

SONG Hong-fei1, DENG Xi1, YANG Ning1, HAO Bo1, HU Yu-bo1, SHI Yan-wei1,2, XUE Li1,2, ZHAO Hu1,2   

  1. 1. Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; 2. Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Guangzhou 510080, China
  • Online:2020-06-25 Published:2020-06-28

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摘要： 目的 探索司法精神病鉴定中脑外伤所致精神障碍者的冲动控制能力及其事件相关电位（event-related potential，ERP）特点，以期为司法精神病鉴定提供客观辅助指标。 方法 收集脑外伤所致精神障碍、经司法精神病鉴定为轻度精神障碍的患者（脑外伤组） 30例，其中男性24例、女性6例，以及对照组30例。两组被试均需完成自评量表Barratt冲动性量表-11（Barratt Impulsiveness Scale-11，BIS-11）和Go/NoGo任务诱导的事件相关电位，收集并分析BIS-11及ERP数据。 结果 BIS-11量表结果表明，脑外伤组的量表总得分及各维度得分高于对照组（P<0.05）。与对照组相比，脑外伤组的NoGo-N2波幅、NoGo-P3波幅低于对照组，两组中NoGo-N2波幅均大于Go-N2波幅，NoGo-P3波幅均大于Go-P3波幅（P<0.05）。 结论 脑外伤可致轻度精神障碍者冲动控制能力受损，NoGo-N2、NoGo-P3波幅可作为脑外伤所致精神障碍者冲动控制能力评定的重要参考指标。

关键词: 司法精神病学, 精神障碍, 脑损伤, 冲动控制障碍, 事件相关电位, Go/NoGo任务, Barratt冲动性量表-11

Abstract: Objective To explore the impulse control and event-related potential （ERP） characteristics of patients with mental disorders caused by traumatic brain injury （TBI） in forensic psychiatry identification and to provide objective auxiliary indicators for forensic psychiatry identification. Methods Thirty patients （TBI group） with mental disorders caused by traumatic brain injury, who were identified as mild psychiatric impairment by judicial psychiatry, including 24 males and 6 females, as well as the thirty people in the control group participated in the study. All the participants completed Barratt Impulsiveness Scale-11 （BIS-11） and ERP induced by Go/NoGo tasks. BIS-11 and ERP data were collected and analyzed. Results The results of the BIS-11 showed that the total score and subscale scores of the TBI group were higher compared to the control group （P<0.05）. Moreover, the TBI group exhibited significantly lower NoGo-N2 amplitude and lower NoGo-P3 amplitude than the control group. The NoGo-N2 amplitude was larger than the Go-N2 amplitude, and the NoGo-P3 amplitude was larger than the Go-P3 amplitude in both groups （P<0.05）. Conclusion Traumatic brain injury could impair impulse control of mild psychiatric impairment patients, and the amplitudes of NoGo-N2 and NoGo-P3 could be important parameters to evaluate the impulse control of patients with mental disorders caused by traumatic brain injury.

Key words: forensic psychiatry, mental disorders, brain injuries, impulse control disorders, event-related potentials, Go/NoGo task, Barratt Impulsiveness Scale-11