法医学杂志

法医学杂志 ›› 2016, Vol. 32 ›› Issue (3): 176-179.DOI: 10.3969/j.issn.1004-5619.2016.03.004

• 论著 • 上一篇    下一篇

听力正常人的长潜伏期听觉诱发电位

刘  会1，2，3，郑  剑1，3，杨小萍3，朱广友3   

  1. （1. 南昌大学司法医学鉴定研究所，江西 南昌 330019； 2. 南昌大学基础医学重点实验室，江西 南昌 330019； 3. 司法部司法鉴定科学技术研究所 上海市法医学重点实验室，上海 200063）
  • 发布日期:2016-06-25 出版日期:2016-06-28
  • 通讯作者: 郑剑，男，硕士，讲师，主检法医师，主要从事法医学教学、鉴定工作；E-mail：zhengjian2004@163.com
  • 作者简介:刘会（1984—），女，硕士，主检法医师，主要从事法医学鉴定工作；E-mail：hhcomeon@126.com

Research on Auditory Long Latency Response in Normal Hearing Subjects

LIU HUI1,2,3, ZHENG JIAN1,3, YANG XIAO-PING3, ZHU GUANG-YOU3   

  1. （1. Institute of Forensic Medicine, Nanchang University, Nanchang 330019, China; 2. Key Laboratory of Basic Medical Sciences of Nanchang University, Nanchang 330019, China; 3. Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China, Shanghai 200063, China）
  • Online:2016-06-25 Published:2016-06-28

摘要： 目的 探索长潜伏期听觉诱发电位（auditory long latency response，ALR）潜伏期、波幅与声刺激强度间的关系和特点，并探讨其在听阈评估中的意义。 方法 对46名听力正常人（92耳）进行ALR测试，予受试者从70、50、30、20至10 dB nHL 5个声刺激强度顺序诱发ALR波形，标记N1波、P2波，得出三个观察指标（N1波及P2波潜伏期、N1-P2波幅）的数值。分析观察三个指标的变化趋势及频率差异性。 结果 46名听力正常人（92耳）ALR波形的引出率均为100%。随着声刺激的降低，ALR的N1波、P2波潜伏期延长，N1-P2波幅降低。 结论 在适宜的条件下，ALR是一项稳定的检测技术。ALR的N1波、P2波潜伏期及N1-P2波幅与声刺激强度间的关系对ALR应用于听阈评估中有重要作用。

关键词: 法医学；诱发电位, 听觉；潜伏期；正常人

Abstract: Objective To explore the characters and the relationship among latency response, amplitude and sound stimulus intensity of auditory long latency response（ALR）, and to investigate the significance of ALR applied in auditory threshold prediction. Methods Total 46 subjects （92 ears） with normal hearing were tested by ALR. The ALR waves of the subjects were elicited by 5 sound stimulus intensity according to the order of 70, 50, 30, 20 and 10 dB nHL. By making N1 wave and P2 wave, the values of 3 observed indexes （the latencies of N1 wave and P2 wave and N1-P2 amplitude） were obtained, and the variation trend of the observed indexes were statistically analyzed. The differences in the frequency of the indexes were observed. Results The rate of ALR waves from 46 subjects （92 ears） with normal hearing was 100%. The latencies of N1 wave and P2 wave delayed gradually and N1-P2 amplitude declined with sound stimulus intensity descending. Conclusion In suitable conditions, ALR is a stable technology for hearing thresholds prediction. The relation between sound stimulus intensity and latency of N1 wave, latency of P2 wave and N1-P2 amplitude of ALR plays an important part in auditory thresholds assessment.

Key words: forensic medicine, evoked potentials, auditory, latency, the normal

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