法医学杂志

法医学杂志 ›› 2015, Vol. 31 ›› Issue (2): 105-108.DOI: 10.3969/j.issn.1004-5619.2015.02.007

• 论著 • 上一篇    下一篇

微视野与视诱发电位在黄斑病变中的法医学应用

周  姝1，2，刘冬梅2，3，彭书雅1，3，孙  婧1，4，刘瑞珏1，夏文涛1   

  1. （1. 复旦大学上海医学院法医学系，上海200032； 2. 司法部司法鉴定科学技术研究所 上海市法医学重点实验室，上海200063； 3. 苏州大学医学部法医学系，江苏 苏州 215123； 4. 华东政法大学研究生教育学院，上海 200042）
  • 发布日期:2015-04-25 出版日期:2015-04-28
  • 通讯作者: 夏文涛，男，主任法医师，硕士研究生导师，主要从事法医临床学的鉴定与研究；E-mail：xiawt@ssfjd.cn 刘瑞珏，女，主任法医师，主要从事法医临床学的鉴定与研究；E-mail：liurj@ssfjd.cn
  • 作者简介:周姝（1989—），女，江苏苏州人，硕士研究生，主要从事法医临床学研究；E-mail：outaa1@163.com
  • 基金资助:

    “十二五”国家科技支撑计划项目（2012BAK16B03）；上海市法医学重点实验室资助项目（14DZ2270800）

Forensic Application of Microperimetry and Visual Evoked Potential in Macular Disease

ZHOU SHU1,2, LIU DONG-MEI2,3, PENG SHU-YA1,3, SUN JING1,4, LIU RUI-JUE1, XIA WEN-TAO1   

  1. （1. Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai 200030, China; 2. Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R. China, Shanghai 200063, China; 3. Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China; 4. Graduate School of East China University of Political Science and Law, Shanghai 200042, China）
  • Online:2015-04-25 Published:2015-04-28

摘要： 目的 研究微视野仪与视诱发电位检测结果与最佳矫正视力的相关性，探索检测眼底黄斑病变者最佳矫正视力的途径。 方法 对62例黄斑病变者（黄斑病变组，62眼）及18例健康志愿者（对照组，36眼）进行最佳矫正视力、微视野仪及视诱发电位的检测。 结果 （1）微视野仪检测示黄斑病变组视网膜平均敏感度、固视百分率均低于对照组，置信椭圆面积均大于对照组；视诱发电位检测示0.5周期/度（circle per degree，cpd）及2 cpd P100波振幅较对照组降低，潜伏期延长（P<0.05）。（2）黄斑病变组最佳矫正视力与其视网膜平均敏感度、置信椭圆面积及黄斑中心2°、4°固视百分率之间呈正相关性（P<0.05）。视网膜平均敏感度与P100波的振幅呈线性相关（P<0.05）。（3）多元线性回归方程为y=0.053 x1+0.008 x3+3.897（y为最佳矫正视力，x1、x3分别为视网膜平均敏感度与2 cpd P100波振幅）。 结论 联合使用微视野仪与视诱发电位有助于判断黄斑区视网膜病变患者的客观最佳矫正视力。

关键词: 法医学, 诱发电位, 视觉, 黄斑, 微视野

Abstract: Objective To find the correlation between real best corrected visual acuity （BCVA） and testing results of microperimetry and visual evoked potential （VEP） and to explore a new method in recording BCVA in macular disease. Methods Sixty-two patients with macular disease （macular disease group, 62 eyes） and eighteen healthy volunteers （control group, 36 eyes） had BCVA, microperimetry and VEP recorded. Results （1） By microperimetry, the values of retinal mean sensitivity and fixation percentage in macular disease group were lower than that in control group. The bicurve ellipse area in macular disease group was higher than that in control group. By VEP, P100 amplitude under 0.5 cpd and 2 cpd in macular disease group were significantly higher than that in control group and the latency was prolonged （P<0.05）. （2） In macular disease group, BCVA had significant positive correlation with retinal mean sensitivity, bicurve ellipse area, macular central 2°and 4°fixation percentage, respectively （P<0.05）. There was a significant correlation between retinal mean sensitivity and P100 amplitude （P<0.05）. （3） Multiple linear regression equation was y=0.053 x1+0.008 x3+3.897 （y was BCVA, while x1 was retinal mean sensitivity and x3 was P100 amplitude under 2 cpd）. Conclusion Combined use of microperimetry and VEP is useful in the assessment of BCVA in macular disease.

Key words: forensic medicine, evoked potentials, visual, macular lutea, microperymetry

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