法医学杂志

法医学杂志 ›› 2003, Vol. 0 ›› Issue (1): 54-56.

• 论文 • 上一篇    下一篇

创伤性脑损伤与细胞凋亡

史为栋,王孔宝,秦启生   

  1. 青岛市中级人民法院技术室,青岛市中级人民法院技术室,华中科技大学同济医学院法医系 山东 266071 ,山东 266071 ,湖北武汉 430030
  • 发布日期:2003-02-25 出版日期:2003-02-28

Trauma brain injury and apoptosis

SHI WEI-DONG, WANG KONG-BAO, QIN QI-SHENG (PEOPLE'S COURT OF QINGDAO, QINGDAO 266071; DEPARTMENT OF FORENSIC PATHOLOGY,TONGJI MEDICAL COLLEGE OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY,WUHAN,430030)   

  • Online:2003-02-25 Published:2003-02-28

摘要： 综述了创伤性脑损伤后神经细胞凋亡发生的证据、特点及其可能的分子机制。研究资料表明:创伤性脑损伤后存在有细胞凋亡,它与坏死的时序空间分布不同,创伤性脑损伤后的神经细胞凋亡可通过多种不同的途径发生,受多种基因的调控。同时,本文还探讨了创伤性脑损伤后神经细胞凋亡的研究在法医学方面的应用。

关键词: 脑损伤, 细胞凋亡, 发生机制

Abstract: The evidence and the feature of apoptosis following tyrauma brain injury(TBI) and the possible mechanisms underlying apoptosis were reviewed. Recently research showed that apoptosis play an important role in TBI, the occurring time and area of apoptosis were found significant differences compared with that of necrosis. The neural cell apoptosis can undergo following many pathways after TBI. In our review, the foreground of apoptosis after TBI research in forensic pathology were also discussed.

Key words: brain injury, apoptosis, pathogenesis