法医学杂志

法医学杂志 ›› 2008, Vol. 0 ›› Issue (1): 8-11.

• 论文 • 上一篇    下一篇

实验大鼠轻中型闭合性脑损伤昏迷指标与分级标准

于建云;李俊祥;郭泽云;赵小林;赵旭东;   

  1. 昆明医学院法医学院,昆明医学院法医学院,昆明医学院组胚教研室,昆明医学院法医学院,昆明医学院精神病学教研室 云南昆明650031 昆明医学院脑损伤研究室,云南昆明650031,云南昆明650031,云南昆明650031,云南昆明650031,云南昆明650031
  • 发布日期:2008-02-25 出版日期:2008-02-28

Coma Criterion and classification Standard of Mild and Moderate Traumatic Brain Injury in Rats

YU JIAN-YUN1,3, LI JUN-XIANG1, GUO ZE-YUN2, ZHAO XIAO-LIN1, ZHAO XU-DONG4 (1.DEPARTMENT OF FORENSIC MEDICINE, KUNMING MEDICAL COLLEGE, KUNMING 650031,CHINA;2.DEPARTMENT OF HISTOLOGY AND EMBRYOLOGY, KUNMING MEDICAL COLLEGE, KUNMING 650031,CHINA;3.DEPARTMEN   

  • Online:2008-02-25 Published:2008-02-28

被引次数

76

摘要： 目的为使实验室间的研究数据可比,特建立大鼠轻型和中型闭合性脑损伤分级的昏迷量化标准。方法利用自制金属单摆装置复制大鼠脑损伤动物模型,按照大鼠脑损伤后昏迷反应程度进行呼吸暂停时间,角膜反射、外耳道刺激反应、翻正反射及针刺疼痛反应消失后恢复时间的实际测量与评分,结合肉眼颅脑解剖检查进行验证,对前述指标的实测值和评分赋值数据进行多元判别回归分析,建立判别方程。结果应用实测值和评分值进行轻型脑损伤判别的概率分别是88.9%和91.9%。结论该标准是一个较理想实用的大鼠轻、中型脑损伤分级标准。

关键词: 法医病理学, 大鼠, 脑损伤, 昏迷, 分级标准

Abstract: Objective To set up a classification standard of mild and moderate traumatic brain injury,for the purpose of reliable data comparison derived from different laboratories. Methods Traumatic brain injury (TBI) in rats was prepared by using a metallic pendulum-striker device. After injury, five variable parameters including the time of apnea and the areflexia, time of corneal reflex, external auditory canal stung reaction, body-righting reflex and needling reaction were determined and scored by using rat coma criterion. These data were judged and classified into mild and moderate head injury by brain patho-anatomy changes. Then the data were used to set up a multivariate discriminate equation.Results The distinguished probability of mild and moderate TBI according to actual direct measured value and the criterion were 88.9% and 91.9%, respectively. Conclusion This method is able to classify mild and moderate TBI in rats.

Key words: forensic pathology, rats, traumatic brain injury, coma, classification standard