法医学杂志

法医学杂志 ›› 2010, Vol. 0 ›› Issue (2): 132-136.

• 论文 • 上一篇    下一篇

低拷贝模板DNA分型及其在法医学中的应用

马妍;匡金枝;侯一平;   

  1. 四川大学华西基础医学与法医学院;天津市公安局物证鉴定中心;
  • 发布日期:2010-04-25 出版日期:2010-04-28

Low Template DNA Profiling and Its Application in Forensic Science

MA YAN1,2,KUANG JIN-ZHI2,HOU YI-PING1 (1. WEST CHINA SCHOOL OF PRECLINICAL AND FORENSIC MEDICINE,SICHUAN UNIVERSITY,CHENGDU 610041,CHINA; 2. THE EVIDENCE IDENTIFYING CENTER OF TIANJIN PUBLIC SECURITY BUREAU,TIANJIN 300384,CHINA)   

  • Online:2010-04-25 Published:2010-04-28

被引次数

15

摘要： 近年来,低拷贝模板类生物物证在法庭科学领域中的应用越来越广泛。然而由于其自身存在的一些限制性因素,始终是法庭科学工作者关注的一个焦点。本文从低拷贝模板DNA的定义及其在法庭科学应用中的有效性、应用范围、分型策略、质量控制、重复性原则、随机阈值等方面对低拷贝数分型及其在法庭科学应用中的最新研究进展进行了综述。

关键词: 法医遗传学, 模板, 遗传, 综述[文献类型], 低拷贝数

Abstract: Low template DNA(LTDNA) has been widely applied in the field of forensic science in recent years. However,the application of low copy number(LCN) analysis is still controversial in certain forensic casework because of its inherent limiting factors. This paper focus on the definition of LCN and LTDNA,the validity and application of LCN in forensic science,methods of typing,quality control,replicate analy-sis,detection thresholds and then reviews the latest development of LCN in forensic science.

Key words: forensic genetics, templates, genetic, review[publication type], low copy number