法医学杂志

法医学杂志 ›› 1996, Vol. 0 ›› Issue (1): 0-0.

• 论文 •    

铁在自由基介导的脑水肿中的作用

朱少华，王大进，龚云鹤，张玲莉   

  1. 同济医科大学法医学系神经病理研究室
  • 发布日期:1996-02-25 出版日期:1996-02-28

Effects of Iron on Free Radical Mediated Brain Edema

ZHU SHAOHUA; GONG YUNHE; ZHANG LINGLI,WANG DAJIN (DEPARTMENT OF FORENSIC MEDICINE,TONGJI MEDICAL UNIVERSITY; HUBEI 430030)   

  • Online:1996-02-25 Published:1996-02-28

被引次数

11

摘要： 利用冷冻制成家兔局灶性脑损伤，术后２、８、１２及２４小时处死动物。测定脑组织中铁、水、脂质过氧化物（ＬＰＯ）及超氧化物歧化酶（ＳＯＤ）水平．结果表明，术后脑组织中铁、水及ＬＰＯ含量均显著升高（Ｐ＜０．０１），而ＳＯＤ活性则显著下降（Ｐ＜０．０１）。且铁含量的升高与水含量及ＬＰＯ含量的升高有着显著的相关关系。说明铁在自由基介导的脑脂质过氧化及脑水肿的发生发展中起着重要作用。

关键词: 铁, 自由基, 脑水肿, 脂质过氧化物

Abstract: Local cerebral lesion of rabbits were produced by conical freezing technique and the rabbits were killed at 2, 8,12 and 24 hours. The iron, water content and the lipid peroxidation (LPO) in the cercbra wete measured and the activity of superoxide dismutaseSOD) was also detected. The results showed the iron, water content and LPO of the cerebra were increased significantly (P<0.01).Nevertheless the correlate analysis found it has a significant relationship between iron with water content and LPO.Those study indicated that iron medicated lipid peroxidate play a important role in the genesis of brain edema.

Key words: iron, free radical, brain edema, lipid peroxidation