法医学杂志

法医学杂志 ›› 2008, Vol. 0 ›› Issue (4): 284-287.

• 论文 • 上一篇    下一篇

胆囊收缩素基因单核苷酸多态性与精神状态的关系及法医学意义

杨俊;王保捷;丁梅;庞灏;孙雪菲;李忠杰;   

  1. 中国医科大学法医学院;
  • 发布日期:2008-08-25 出版日期:2008-08-28

The Relationship between SNP of Cholecystokinin Gene and Certain Mental Status and its Forensic Significance

YANG JUN,WANG BAO-JIE,DING MEI,PANG HAO,SUN XUE-FEI,LI ZHONG-JIE(SCHOOL OF FORENSIC MEDICINE,CHINA MEDICAL UNIVERSITY,SHENYANG 110001,CHINA)   

  • Online:2008-08-25 Published:2008-08-28

摘要： 胆囊收缩素(cholecystokinin,CCK)是一种具有广泛生物学活性的脑肠肽,既是胃肠道主要调节激素之一,还广泛存在于中枢及外周神经系统中以神经递质或神经调质的形式发挥重要的生理作用。近年来国内外研究发现,CCK基因上存在多个单核苷酸多态性(single nucleotide polymorphisms,SNP)位点,其中-45C/T,-196G/A变异与多种精神状态如精神分裂症、抑郁症、自杀行为、帕金森病等存在一定的相关性。这些SNP多态性可应用于法医物证学的亲子鉴定和个人识别,并且可能成为某些特殊案例如涉及精神病鉴定、法医病理学的疾病鉴定、异常行为(自杀倾向等)鉴定的辅助指标之一。

关键词: 司法精神病学, 胆囊收缩素, 综述[文献类型], 多态性, 单核苷酸, 精神状态

Abstract: Cholecystokinin(CCK) is a brain-gut peptide with broad biological activities.It is one of the main regulating hormones in the digestive system,and it plays an important physiological role in the central and peripheral nervous system as a neurotransmitter or a neuromodulator.Recently,many reports have demonstrated that there were a number of SNPs on CCK gene,of which -45C/T and -196G/A showed certain correlation with a variety of psychiatric states such as schizophrenia,depressive disorder,suicidal behavior,Parkinson′s disease,etc.These SNPs may be used in paternity testing and personal identification.In addition,it may also become one of the auxiliary indicators in some special cases of forensic pathology.

Key words: forensic psychiatry, cholecystokinin, review publication type, polymorphism, single nucleotide, mental status