法医学杂志

法医学杂志 ›› 2009, Vol. 0 ›› Issue (6): 443-446.

• 论文 • 上一篇    下一篇

NMDA受体拮抗剂与精神分裂症动物模型

卞士中;张健;刘伟丽;孙志红;顾振纶;蒋小岗;   

  1. 苏州大学医学部法医学系;苏州中药研究所;苏州大学衰老与神经疾病实验室;
  • 发布日期:2009-12-25 出版日期:2009-12-28

Receptor Antagonist of NMDA and Animal Models of Schizophrenia

BIAN SHI-ZHONG1, ZHANG JIAN1,2, LIU WEI-LI1, SUN ZHI-HONG1, GU ZHEN-LUN2,3, JIANG XIAO-GANG2,3 (1. DEPARTMENT OF FORENSIC MEDICINE, MEDICAL COLLEGE OF SOOCHOW UNIVERSITY, SUZHOU 215123, CHINA; 2. SUZHOU INSTITUTE OF CHINESE MATERIA MEDICA, SUZHOU 215006,   

  • Online:2009-12-25 Published:2009-12-28

被引次数

15

摘要： 精神分裂症是一类常见的精神疾病之一,由于其发病机制复杂,到目前为止病因尚未完全阐明,N-甲基-D-天门冬氨酸(N-methyl-D-aspartate,NMDA)受体拮抗剂能够较好地模拟精神分裂症的阳性症状、阴性症状以及认知功能障碍,近年来被广泛用以制作精神分裂症的动物模型。本文综述了苯环利定、地佐西平和氯胺酮这3种NMDA离子通道开放阻断剂与建立精神分裂症动物模型的关系。

关键词: 司法精神病学, 精神分裂症, 综述[文献类型], 受体, N-甲基-D-天冬氨酸

Abstract: Schizophrenia is one of the common mental diseases. Because the mechanism of the schizophrenia is significantly complicated,the cause is still unknown. N-methyl-D-aspartate receptor antagonist can simulate the positive and negative symptoms, as well as the cognitive disorder of schizophrenia. Thus it has been widely used to establish the animal models of schizophrenia. The relationship of the three blocking agents of ion channels (phencyclidine, MK-801, ketamine) and the establishment of schizophrenia animal models is reviewed in this article.

Key words: forensic psychiatry, schizophrenia, review[publication type], receptors, N-methyl-D-aspartate