法医学杂志

法医学杂志 ›› 2013, Vol. 29 ›› Issue (5): 365-367,377.DOI: 10.3969/j.issn.1004-5619.2013.05.012

• 综述 • 上一篇    下一篇

金属硫蛋白-Ⅰ/Ⅱ在脑损伤修复中的机制及其法医学应用

李  东，李如波，林巨里   

  1. （中国医科大学法医学院法医病理学研究室，辽宁 沈阳 110001）
  • 发布日期:2013-10-25 出版日期:2013-10-28
  • 通讯作者: 李如波，男，博士，教授，主要从事脑死亡及弥漫性脑损伤的法医病理学研究；E-mail：rbli@mail.cmu.edu.cn
  • 作者简介:李东（1993—），女，辽宁葫芦岛人，临床医学七年制学生，主要从事法医病理学研究；E-mail：ldcdl2010@163.com
  • 基金资助:

    辽宁省教育厅科学研究一般项目（L201331）

Metallothionein-Ⅰ/Ⅱ in Brain Injury Repair Mechanism and Its Application in Forensic Medicine

LI DONG, LI RU-BO, LIN JU-LI   

  1. （Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110001, China）
  • Online:2013-10-25 Published:2013-10-28

摘要： 金属硫蛋白（metallothionein，MT）是一种金属结合蛋白，其中MT-Ⅰ/Ⅱ是其重要成员，能够调节脑内金属离子代谢和解毒以及清除自由基，具有抗炎症反应和抗氧化应激的作用，对脑组织有保护作用。最新研究表明，MT-Ⅰ/Ⅱ可刺激脑内抗炎因子、生长因子、神经营养因子及其受体的表达，并可促进神经元轴突延长，有利于神经元再生，在脑损伤修复过程中起重要作用。基于这些发现，本文对MT-Ⅰ/Ⅱ的结构、表达、分布、调节，在脑损伤修复中的作用及机制，同时也对其在法医学中的应用前景进行阐述，为脑损伤药物的研制和脑创伤时间的推断提供新的思路。

关键词: 法医病理学, 金属硫蛋白, 综述[文献类型], 脑损伤

Abstract: Metallothionein （MT） is a kind of metal binding protein. As an important member in metallothionein family, MT-Ⅰ/Ⅱ regulates metabolism and detoxication of brain metal ion and scavenges free radicals. It is capable of anti-inflammatory response and anti-oxidative stress so as to protect the brain tissue. During the repair process of brain injury, the latest study showed that MT-Ⅰ/Ⅱ could stimulate brain anti-inflammatory factors, growth factors, neurotrophic factors and the expression of the receptor, and promote the extension of axon of neuron, which makes contribution to the regeneration of neuron and has important effect on the recovery of brain injury. Based on the findings, this article reviews the structure, expression, distribution, adjustion, function, mechanism in the repair of brain injury of MT-Ⅰ/Ⅱ and its application prospect in forensic medicine. It could provide a new approach for the design and manufacture of brain injury drugs as well as for age estimation of the brain injury.

Key words: forensic pathology, metallothionein, review [publication type], brain injury

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