法医学杂志

法医学杂志 ›› 2020, Vol. 36 ›› Issue (1): 115-119.DOI: 10.12116/j.issn.1004-5619.2020.01.022

• 综述 • 上一篇    下一篇

乙醇-乌头碱致心律失常的毒理分子机制研究进展

潘美辰1， 周小伟2， 刘艳1， 王宇宁1， 邱鑫罡1， 吴士凡1， 刘茜1   

  1. 1. 华中科技大学同济医学院法医学系，湖北 武汉 430030； 2. 湖北崇新司法鉴定中心，湖北 武汉 430403
  • 发布日期:2020-02-25 出版日期:2020-02-28
  • 通讯作者: 刘茜，女，副教授，博士，主要从事法医病理学和法医毒理学研究；E-mail：caixe_liu0222@tom.com
  • 作者简介:潘美辰（1993—），女，硕士研究生，主要从事法医病理学和法医毒理学研究；E-mail：1148005372@qq.com
  • 基金资助:
    国家自然科学基金资助项目（81102299）；教育部博士点新教师资助基金（20110142120034）；法医学山西省重点实验室开放课题资助基金（SFM2018002）

Research Progress on the Molecular Mechanisms of Toxicology of Ethanol-Aconitine Induced Arrhythmia

PAN Mei-chen1, ZHOU Xiao-wei2, LIU Yan1, WANG Yu-ning1, QIU Xin-gang1, WU Shi-fan1, LIU Qian1   

  1. 1. Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; 2. Hubei Chongxin Judicial Expertise Center, Wuhan 430403, China
  • Online:2020-02-25 Published:2020-02-28

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摘要： 乌头属植物是广泛使用的中草药代表之一，乌头碱是其中最主要的毒性成分，主要引起多种心律失常而致死。急性乙醇摄入也可引起心律失常。法医学实践中常遇到乌头类药酒引起的中毒案例。这两者的心肌毒性分子机制有较多共通点，均对心肌细胞膜钠通道、钙通道及钾通道等产生影响。本文通过综述近年来乙醇、乌头碱心脏毒性机制的研究报道，分析讨论乙醇-乌头碱可能共同影响的心肌细胞通道蛋白，为联合中毒致心律失常的分子机制研究提供思路与参考。

关键词: 法医毒理学, 中毒, 乙醇, 乌头碱, 心律失常, 综述

Abstract: Aconitum is one of the most widely used Chinese herbal medicines, and aconitine is the major toxic component in it. Aconitine can induce a variety of arrhythmias, resulting in death. Acute ethanol consumption causes arrhythmia as well. Poisoning cases caused by aconitum medicinal liquor are frequently encountered in the practice of forensic medicine. The molecular mechanisms of myocardial toxicity of these two drugs have much in common, and both of them affect the sodium channel, calcium channel and potassium channel of myocardial cell membrane and so on. This paper analyzes and discusses the possible co-effects of ethanol-aconitine on cardiomyocyte channel proteins, by reviewing researches on the mechanism of cardiotoxicity of ethanol and aconitine in recent years, in order to provide ideas and references for the research on the molecular mechanism of arrhythmia caused by combined poisoning.

Key words: forensic toxicology, poisoning, ethanol, aconitine, arrythmia, review