The application of microwave irradiation to derivatization

Abstract

Abstract: The methods using microwave irradiation for rapidpreparation of acetyl, trifluoroacetyl, pentafluoropyl,heptafluorobutyl and MSTFA derivatives ofMorphine, AMP and MAMP were developed.Conventional techniques for the reaction mixture tobe heated need 30 min at 60-70"C to formderivatizations, but by microwave irradiation, only2-3 min is needed. The mass spectral fragmentationpatterns and gas chromatographic retention times ofthe derivatives obtained by both microwaveirradiation and conventional heating are similar.

Key words: microwave irradiation, derivatization, morphine, amphetamine

SHEN MIN;SHEN BAOHUA (INSTITUTE OF FORENSICSCIENCE;MINISTRY OF JUSTICE;PRC. GUANGFUXIRD;SHANGHAI 000J). The application of microwave irradiation to derivatization[J]. , 1997, 0(4): 200-202+.

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