The polymophic study of HLA-DRB1 gene in Chinese Liaoning Han with PCR-Sequence specific primers

Abstract

Abstract: 8 allele and group specificity at HLA - DRB1 locuswere genotyped in 159 Unrelated individuals of Liaoning Han,with polymerase chain reaction - sequence specific primers.The range of gene frequencies was from 0 .02201 - 0 .23899.Heterozagosity was 83%. 33 out of 36 theoretical genotypeswere identified and the result conformed to Hardy- Weinbergequilibrium law. The present method can be used not only inpaternity test, individual identification, but also in clinicgraft matching between donor and recipient as well as thestudy of HLA.

Key words: HLA-DRB1 gene, PCR, gene frequency

LIU LIMIN;HU SHU;JIA JINGTAO (DEPARTMENT OF FORENSICMEDICINE;CHINA MEDIAL UNIVERSISY;SHENYANG 000). The polymophic study of HLA-DRB1 gene in Chinese Liaoning Han with PCR-Sequence specific primers[J]. , 1998, 0(4): 204-206+.

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The polymophic study of HLA-DRB1 gene in Chinese Liaoning Han with PCR-Sequence specific primers

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