Abstract: The basic changes are to transform the levels of many genes' transcriptions and translations when methamphetamine is injected into the organism.Those genes enclose four classes:genes intermediating the dam-ages or death of neurons,genes involving circadian rhythms of activity,genes concerning the abnormality of be-haviors and some genes difficult to be classified.The transformations of the transcriptions or translations of these genes cooperate to produce many clinic syndromes of methamphetamine-addictors.Moreover,the study of these genes can provide testimonies to forensic identification.

Key words: methamphetamine, Bcl-2gene family, HSP70gene family, arc gene, C-fos, preprodynorphin gene, zif/268gene