Abstract: Individual identification plays an import role in the practice of forensic medicine, and often provides crucial evidence for the analysis and detection of criminal cases. However, for individual identification in complex situations, such as monozygotic （MZ） twins assumed to be genetically identical, it is impossible to distinguish one from the other by using traditional forensic DNA typing system. Therefore, how to discriminate the MZ twins has become and will continue to be one of the difficult problems in forensic field. This paper summarized the genetic and epigenetic changes recently identified in MZ pairs, which might provide a new insight to forensic discrimination of MZ twins.

Key words: forensic genetics, epigenetics, individual identification, monozygotic twins, review