Journal of Forensic Medicine

法医学杂志 ›› 2019, Vol. 35 ›› Issue (5): 537-544.DOI: 10.12116/j.issn.1004-5619.2019.05.006

Special Issue: 人体表征分子鉴识

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Research Progress on Age Estimation Based on DNA Methylation#br#

MENG Hang1,2,3, MA Kai-jun1,2, DONG Li-min4, LI Cheng-tao5, XIAO Bi1,2, XU Lu-yi1,2, HUANG Ping5, XIE Jian-hui3   

  1. 1. Shanghai Key Laboratory of Crime Scene Evidence, Shanghai 200083, China; 2. Institute of Forensic Science, Shanghai Municipal Public Security Bureau, Shanghai 200083, China; 3. Department of Forensic Medicine, Fudan University, Shanghai 200032, China; 4. Minhang Branch of Shanghai Municipal Public Security Bureau, Shanghai 201108, China; 5. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China
  • Online:2019-10-25 Published:2019-10-28

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Abstract: Age estimation is of great significance in the fields of criminal investigation and forensic identification. It can provide the age information of individuals to judicial departments to facilitate the development of judicial work. In recent years, age estimation methods expanded from the morphological level to the molecular biology level. With the rapid development of epigenetics represented by DNA methylation, and the advancement of DNA methylation detection technology together with the detection platform, many age estimation methods based on DNA methylation biomarkers, or using several biological fluids, such as blood, blood stains, saliva, semen stains, etc. are developed. Currently, researches related to age estimation based on DNA methylation are relatively widely carried out. This paper summarizes the researches on age estimation based on DNA methylation, in order to provide references for related studies and forensic applications.

Key words: forensic genetics, DNA methylation, age determination, review