Abstract: Objective A rapid and selective method has been developed for the determination of propofol in blood by gas chromatography-mass spectrometry (GC-MS). Methods The blood was extrasted with the solution of internal standard, the extracted residue was analyzed by gas chromatography-mass spectrometry using selected-ion monitoring mode. Results The linear range was 0.1-10 μg/mL. The coefficient(R2) was 0.993 1. The detection limit was 0.05 μg/mL. Conclusion The method is simple and rapid, offering superior sensitivity and selectivity for propofol. The method can be used successfully during clinical and forensic toxicology.

Key words: GC-MS, propofol, blood