The Role of Dopamine D3 Receptor in the Amphetamine-induced Conditioned Place Preference in Mice

Abstract

Abstract: Objective To study the role of dopamine D3 receptor involved in the amphetamine-induced conditioned place preference (CPP) in mice. Methods The CPP was observed in D3 receptor knock-out (D3RKO) mice and C57BL/6 wild-type control mice after administration of amphetamine. The data were analyzed with a two-way ANOVA using the SPSS 13.0 software. Results D3RKO mice showed a significant amphetamine-induced CPP (P<0.001), compared with the ones administered with saline in C57BL/6 control mice. Conclusion The results indicate that amphetamine can produce significant CPP in dopamine D3 receptor knock-out mice, suggesting that amphetamine-induced addiction can be inhibited by dopamine D3 receptor.

Key words: amphetamine, conditioned place preference, gene knock-out, dopamine D3 receptor, drug addiction

ZHU JUN-YAN;CHEN LI-PING;LI LIN;ZHENG HAI-BO;CHEN TENG;(.DEPARTMENT OF FORENSIC MEDICINE;MEDICAL COLLEGE;XI'AN JIAOTONG UNIVERSITY;XI'AN 00;CHINA;.THE NATIONAL LABORATORY OF THE MINISTRY OF HEALTH FOR FORENSIC;SCHOOL OF MEDIC. The Role of Dopamine D3 Receptor in the Amphetamine-induced Conditioned Place Preference in Mice[J]. , 2007, 0(6): 428-430.

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The Role of Dopamine D3 Receptor in the Amphetamine-induced Conditioned Place Preference in Mice

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