法医学杂志 ›› 2018, Vol. 34 ›› Issue (4): 420-427.DOI: 10.12116/j.issn.1004-5619.2018.04.016

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Research Progress on InDel Genetic Marker in Forensic Science

SHENG Xiang1,2, BAO Yun2,3, ZHANG Jia-shuo1,2, LI Min2,4, LI Ya-nan2,3, XU Qian-nan2,4, ZHANG Su-hua2, LI Cheng-tao2   

  1. 1. Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China; 2. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China; 3. School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010030, China; 4. Department of Forensic Medicine, Wenzhou Medical University, Wenzhou 325035, China
  • Online:2018-08-25 Published:2018-08-28

Abstract: Genetic markers in forensic DNA typing experienced the variable number of tandem repeats (VNTR) sequences and the short tandem repeats (STR) sequences. With the emerge of sequencing technology, the third generation of genetic markers were found out, which usually have two alleles including single nucleotide polymorphism (SNP) and insertion/deletion (InDel), also known as biallelic genetic markers. Because of the insertions or deletions of DNA fragments, InDel genetic marker reveals DNA fragment length polymorphism and widely distributes across the whole genome. InDel genetic marker is numerous and has the characteristics of STR and SNP genetic markers, which has been applied in the fields of genetics and anthropology. This review focuses on the research progress of InDel genetic marker in forensic science, aiming to review and summarize the main research findings in recent years and provide clues for future researches.

Key words: forensic genetics, genetic marker, review, insertion/deletion