Journal of Forensic Medicine

法医学杂志 ›› 2019, Vol. 35 ›› Issue (3): 308-313.DOI: 10.12116/j.issn.1004-5619.2019.03.009

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Genetic Polymorphism of Y Chromosome Haplogroup D-M174 in East Asian Populations

,4, MA Quan2, ZHAO Hui2, LI Cai-xia2,4, HUANG Jiang1, JIANG Li2   

  1. 1. Institute of Forensic Medicine, Guizhou Medical University, Guiyang 550004, China; 2. National Engineering Laboratory for Forensic Science, Beijing Engineering Research Center of Crime Scene Evidence Examination, Key Laboratory of Forensic Genetics, Institute of Forensic Science, Ministry of Public Security, Beijing 100038, China; 3. Zhuzhou Municipal Public Security Bureau, Zhuzhou 412007, Hunan Province, China; 4. Institute of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, China
  • Online:2019-06-25 Published:2019-06-28

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Abstract: Objective To explore the genetic polymorphism of Y chromosome D-M174 haplogroup and sub-haplogroups in East Asia. Methods The samples of 1 426 unrelated male individuals from East Asia were collected, and then 7 Y chromosome haplogroup D-M174 and the Y-SNP of its sub-haplogroups were detected with mini-sequencing. The 22 Y-STR genotypes were detected with DNA Typer Y26 kit. The haplogroup was analyzed using direct counting method, heatmap, phylogenetic cluster and network graph cluster, and then distribution of genetic polymorphism and the clustering relation between populations and samples of Y chromosome D haplogroup were discussed. Results Haplogroup D-M174 were distributed mostly among Tibetans （40.96%）and Japanese （35.71%）, while less or none were distributed among the surrounding areas of Tibet and other areas. Conclusion The geographical distribution of Y chromosome D-M174 haplogroup in East Asian populations has significant characteristics.

Key words: forensic genetics, genetics, population, Y chromosome, polymorphism, haplogroup, D-M174, East Asia