法医学杂志 ›› 2012, Vol. 28 ›› Issue (3): 207-210.DOI: 10.3969/j.issn.1004-5619.2012.03.013

• 综述 • 上一篇    下一篇

磁共振弥散张量成像与质子磁共振波谱技术在脑损伤鉴定中的应用

赵  兆1,于建云1,吴昆华2,余化霖3,刘翱翔1,李玉华1   

  1. (1. 昆明医科大学法医学院,云南 昆明 650500; 2. 云南省第一人民医院,云南 昆明 650032; 3. 昆明医科大学第一附属医院,云南 昆明 650034)
  • 发布日期:2012-06-25 出版日期:2012-06-28
  • 通讯作者: 于建云,男,博士,教授,主要从事法医病理学与脑损伤认知行为研究;E-mail:jianyunyu@sina.com
  • 作者简介:赵兆(1987—),男,安徽广德人,硕士研究生,主要从事法医病理学研究;E-mail:327164152@qq.com
  • 基金资助:

    国家自然科学基金资助项目(30560041);云南省自然科学基金项目(2008CD052)

Application of Diffusion Tensor Imaging and 1H-Magnetic Resonance Spectroscopy in Diagnosis of Traumatic Brain Injury

ZHAO ZHAO1, YU JIAN-YUN1, WU KUN-HUA2, YU HUA-LIN3, LIU AO-XIANG1, LI YU-HUA1   

  1. (1. Department of Forensic Medicine, Kunming Medical University, Kunming 650500, China; 2. Yunnan First People’s Hospital, Kunming 650032, China; 3. The First Affiliated Hospital of Kunming Medical University, Kunming 650034, China)
  • Online:2012-06-25 Published:2012-06-28

摘要: 轻型创伤性颅脑损伤(mild traumatic brain injury,mTBI)是青壮年常见的一类脑功能障碍疾病,其功能损害常常伴随着白质纤维束损伤、轴突断裂水肿改变为基础的弥散性轴索损伤(diffuse axonal injury,DAI)而加剧。因轻、中型脑损伤或DAI损伤具有弥散性与细微性特点,常规CT及MRI检查难有阳性发现。近来临床研究发现功能磁共振成像对急性轻、中型脑损伤的诊断有很高的甄别价值。本文就功能磁共振弥散张量成像(diffuse tensor imaging,DTI)与质子磁共振波谱(1H-magnetic resonance spectroscopy,1H-MRS)技术的原理、特点及近年来在脑损伤临床及动物实验中的应用研究进行综述。

关键词: 法医学, 脑损伤, 综述[文献类型], 磁共振成像, 弥散, 质子磁共振波谱

Abstract: Mild traumatic brain injury (mTBI) is a common type of brain disorders among young adults. The dysfunction of the brain is often exacerbated due to diffuse axonal injury(DAI) which based on the injury of white matter fibers and axons. Since mild and moderate brain injury or DAI are diffuse and subtle, conventional CT and MRI are difficult to make a positive diagnosis. Recent clinical study indicated that functional magnetic resonance imaging has a high detection rate in the diagnosis of acute mild and moderate brain injury, especially the diffusion tensor imaging(DTI) and 1H-magnetic resonance spectroscopy (1H-MRS). This paper has reviewed the principles and characteristics of DTI and 1H-MRS, and recent research in the clinical and animal experiments on brain injury.

Key words: forensic medicine, brain injuries, review[publication type], diffusion magnetic resonance imaging, 1H-magnetic resonance spectroscopy

中图分类号: